0000000000730440

AUTHOR

L. Von Hertzen

showing 3 related works from this author

Airway obstruction in relation to symptoms in chronic respiratory disease—a nationally representative population study

2000

Abstract We examined the severity of airway obstruction and the occurrence of respiratory symptoms in a large, nationally representative population sample and in a subgroup of subjects with chronic bronchitis and/or emphysema to obtain information for developing national prevention and treatment strategies for these diseases. The study population comprised of 7217 randomly selected subjects (aged 30 years and older) who participated in a comprehensive health examination survey. The ‘cases' were subjects diagnosed as having chronic bronchitis and/or emphysema. The survey methods comprised of questionnaires, interviews, physical measurements, including spirometry, and clinical examinations. I…

SpirometryAdultMalePulmonary and Respiratory Medicinemedicine.medical_specialtyChronic bronchitissymptoms.chronic obstructive pulmonary diseaseFEV1/FVC ratioInternal medicineForced Expiratory VolumeSurveys and QuestionnairesOdds RatioPrevalenceMedicineHumansLung Diseases ObstructiveBronchitisFinlandAgedEmphysemamedicine.diagnostic_testbusiness.industryPhlegmRespiratory diseaseSmokinglung functionAirway obstructionMiddle Agedrespiratory systemmedicine.diseaseobstructionrespiratory tract diseasesCold TemperatureChronic coughDyspneaPopulation SurveillanceChronic DiseasePhysical therapyPopulation studychronic bronchitisFemalemedicine.symptombusinessRespiratory Medicine
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Paving the way of systems biology and precision medicine in allergic diseases: the Me DALL success story

2016

MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sen…

0301 basic medicineAllergyeducation.field_of_studybusiness.industrySystems biologyImmunologyPopulationAtopic dermatitisOmicsmedicine.diseasePrecision medicine3. Good healthReview article03 medical and health sciences030104 developmental biology0302 clinical medicine030228 respiratory systemImmunologyImmunology and AllergyMedicinemedia_common.cataloged_instanceEuropean unionbusinesseducationmedia_commonAllergy
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Paving the way of systems biology and precision medicine in allergic diseases: The MeDALL success story

2016

MeDALL Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 20 (10) -2015 proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy(.) MeDALL linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology omics, IgE measurement using micro-arrays and environmental data(.) Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitisation(.) IgE …

multimorbidityBIRTH COHORTIMMUNE-RESPONSESEUROPEAN INNOVATION PARTNERSHIPCHILDHOOD ASTHMAIGE SENSITIZATIONasthmaINTEGRATED CARECHRONIC RESPIRATORY-DISEASESrhinitispolysensitizationATOPIC-DERMATITISIgEIMMUNOLOGICAL REACTIVITYIMMUNOGLOBULIN-E
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