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RESEARCH PRODUCT
Paving the way of systems biology and precision medicine in allergic diseases: the Me DALL success story
Erik MelénErik MelénRudolph ValentaFanny RancièreC. TischerI. SkrindoHamida HammadV. AnastasovaLeda ChatziC. HohmanMagnus WickmanM P FantiniM. TorrentPascal DemolyS. PalkonenEsben EllerCarsten Bindslev-jensenN. AndersonA. BedbrookTorsten ZuberbierRachel NadifFrancesco ForastiereK. WengerSybille KoletzkoI. Annesi-maesanoJonathan M. CoquetYvan SaeysJoachim HeinrichSteffen LauMarit WestmanMarit WestmanBénédicte JacqueminL. Von HertzenM. StandlMarta BenetMartijn J. SchuijsMirela CurinDirkje S. PostmaValérie SirouxBart N. LambrechtE. MininaChristian LupinekVegard HovlandIrina LehmannJordi SunyerDieter MaierStephane BallereauAnna AsarnojAnna AsarnojJean BousquetIsabelle MomasA. Rial-sebbagGerard H. KoppelmanCezmi A. AkdisIsabelle PinA. Von BergHenriette A. SmitManolis KogevinasBeatrix GerhardClaus BachertEmilie BurteS. GuerraSandra WieserBert BrunekreefJohann PelletUlrike GehringRenata KissPetter MowinckelCheng-jian XuAnne Cambon-thomsenJordi MestresTheresa KellerMartijn C. NawijnFerran BallesterN. BallardiniN. BallardiniTari HaahtelaMariona PinartCharles AuffrayJ. Garcia-aymerichJ. JustR. AlbangMarek L. KowalskiMarjan KerkhofInger KullMika J. MäkeläG. De CarloJ. De VochtKai-håkon CarlsenSam OddieA. ArnoRosemary R. C. MceachanX. BasaganaThomas KeilThomas KeilDaniela PortaM. AkdisAnna BergströmNathanaël LemonnierRaphaëlle VarrasoJohn WrightJosep M. AntóK. C. Lødrup CarlsenD. Smagghesubject
0301 basic medicineAllergyeducation.field_of_studybusiness.industrySystems biologyImmunologyPopulationAtopic dermatitisOmicsmedicine.diseasePrecision medicine3. Good healthReview article03 medical and health sciences030104 developmental biology0302 clinical medicine030228 respiratory systemImmunologyImmunology and AllergyMedicinemedia_common.cataloged_instanceEuropean unionbusinesseducationmedia_commondescription
MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-08-23 | Allergy |