0000000000343168

AUTHOR

Charles Auffray

showing 6 related works from this author

Mechanisms of the Development of Allergy (MeDALL) : Introducing novel concepts in allergy phenotypes

2017

Asthma, rhinitis, and eczema are complex diseases with multiple genetic and environmental factors interlinked through IgE-associated and non–IgE-associated mechanisms. Mechanisms of the Development of ALLergy (MeDALL; EU FP7-CP-IP; project no: 261357; 2010-2015) studied the complex links of allergic diseases at the clinical and mechanistic levels by linking epidemiologic, clinical, and mechanistic research, including in vivo and in vitro models. MeDALL integrated 14 European birth cohorts, including 44,010 participants and 160 cohort follow-ups between pregnancy and age 20 years. Thirteen thousand children were prospectively followed after puberty by using a newly standardized MeDALL Core Q…

0301 basic medicineAllergyGenome-wide association studyComorbidityImmunoglobulin Emedicine.disease_causeCohort StudiesTranslational Research Biomedical0302 clinical medicineAllergenREGULATORY B-CELLSPRECISION MEDICINEMedicineBIRTH COHORT INFANTSATOPIC-DERMATITISImmunology and Allergy[SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/AllergologyChildmedia_commonbiologyatopic dermatitisAtopic dermatitis3. Good healthEuropeMulticenter StudyCHRONIC RESPIRATORY-DISEASESrhinitiPhenotypeINNER-CITY CHILDRENBiomarker (medicine)Femaleatopic dermatitiAdolescentEUROPEAN INNOVATION PARTNERSHIPImmunologyreview03 medical and health sciencesEARLY-LIFEYoung AdultrhinitisAllergy ; Asthma ; Atopic Dermatitis ; RhinitisHypersensitivityJournal Articlemedia_common.cataloged_instanceAnimalsHumansEuropean unionAsthmaMOUNTAIN CEDAR POLLINOSISbusiness.industryGene Expression ProfilingCHILDHOOD ASTHMAAllergensImmunoglobulin Emedicine.diseaseallergyAsthma030104 developmental biology030228 respiratory systemImmunologybiology.proteinImmunizationbusinessGenome-Wide Association StudyJournal of Allergy and Clinical Immunology
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Severe Chronic Allergic (and Related) Diseases: A Uniform Approach – A MeDALL – GA<sup>2</sup>LEN – ARIA Position Paper

2012

Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in …

medicine.medical_specialtybusiness.industryPublic healthImmunologymacromolecular substancesGeneral MedicineAtopic dermatitismedicine.disease3. Good health03 medical and health sciences0302 clinical medicine030228 respiratory systemDisease severityEpidemiologyImmunologymedicinePhysical therapyImmunology and AllergyPosition paperDisease process030212 general & internal medicineIntensive care medicinebusinessChronic urticariaAsthmaInternational Archives of Allergy and Immunology
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DNA methylation in childhood asthma

2018

Background: DNA methylation profiles associated with childhood asthma might provide novel insights into disease pathogenesis. We did an epigenome-wide association study to assess methylation profiles associated with childhood asthma. Methods: We did a large-scale epigenome-wide association study (EWAS) within the Mechanisms of the Development of ALLergy (MeDALL) project. We examined epigenome-wide methylation using Illumina Infinium Human Methylation450 BeadChips (450K) in whole blood in 207 children with asthma and 610 controls at age 4–5 years, and 185 children with asthma and 546 controls at age 8 years using a cross-sectional case-control design. After identification of differentially m…

Male0301 basic medicineAllergyCytotoxicT-Lymphocytes[SDV]Life Sciences [q-bio]Respiratory Systemlnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]CHILDRENImmunoglobulin EEpigenesis GeneticChildPOPULATIONeducation.field_of_studybiologyMethylation3. Good healthCpG siteChild PreschoolDNA methylationFemaleBIOS ConsortiumLife Sciences & BiomedicinePulmonary and Respiratory MedicinePopulationPHENOTYPESIMMUNITY03 medical and health sciencesCritical Care MedicineGeneticGeneral & Internal MedicinemedicineHumansCOHORTEpigeneticsIGEEXPOSUREPreschooleducationAsthmaScience & Technologybusiness.industryRHINITISDNADNA Methylationmedicine.diseaseAsthmaEosinophils030104 developmental biology3121 General medicine internal medicine and other clinical medicineImmunologybiology.proteinGENOMEWIDE ASSOCIATIONCpG IslandsbusinessCOLLECTIONT-Lymphocytes CytotoxicEpigenesisGenome-Wide Association StudyThe Lancet. Respiratory Medicine
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Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) seminar.

2012

Mechanisms of the Development of Allergy (MeDALL), a Seventh Framework Program European Union project, aims to generate novel knowledge on the mechanisms of initiation of allergy. Precise phenotypes of IgE-mediated allergic diseases will be defined in MeDALL. As part of MeDALL, a scientific seminar was held on January 24, 2011, to review current knowledge on the IgE-related phenotypes and to explore how a multidisciplinary effort could result in a new integrative translational approach. This article provides a summary of the meeting. It develops challenges in IgE-related phenotypes and new clinical and epidemiologic approaches to the investigation of allergic phenotypes, including cluster a…

AllergyAllergyWORLD-HEALTH-ORGANIZATIONBioinformaticsEpigenesis Genetic0302 clinical medicineRisk FactorsImmunology and AllergyMedicineYoung adultChildEpigenesismedia_commonMechanisms of the Development of Allergy0303 health scienceseducation.field_of_studyphenotypesAllergy; Mechanisms of the Development of Allergy; Seventh Framework Program; phenotypes; IgE; asthmaRUSSIAN KARELIAPhenotype3. Good healthLUNG-FUNCTIONPhenotypeChild PreschoolBRONCHIAL HYPERRESPONSIVENESSIgEBIRTH-COHORTAdolescentASTHMA RESEARCH-PROGRAMSystems biologyImmunologyPopulationOBSTRUCTIVE PULMONARY-DISEASEYoung Adult03 medical and health sciencesDIAGNOSTIC GATEKEEPERSHypersensitivityAnimalsHumansmedia_common.cataloged_instanceEuropean unioneducation030304 developmental biologyCLUSTER-ANALYSISbusiness.industryMechanism (biology)ResearchImmunoglobulin Easthmamedicine.disease030228 respiratory systemSeventh Framework ProgramImmunologybusinessT-REGULATORY-CELLS
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Paving the way of systems biology and precision medicine in allergic diseases: the Me DALL success story

2016

MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sen…

0301 basic medicineAllergyeducation.field_of_studybusiness.industrySystems biologyImmunologyPopulationAtopic dermatitisOmicsmedicine.diseasePrecision medicine3. Good healthReview article03 medical and health sciences030104 developmental biology0302 clinical medicine030228 respiratory systemImmunologyImmunology and AllergyMedicinemedia_common.cataloged_instanceEuropean unionbusinesseducationmedia_commonAllergy
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Making sense of big data in health research: {T}owards an {EU} action plan

2016

Genome medicine 8(1), 71 (2016). doi:10.1186/s13073-016-0323-y

0301 basic medicineBiomedical ResearchDatabases FactualPREDICTIONComputer scienceBig data: Santé publique services médicaux & soins de santé [D22] [Sciences de la santé humaine]XXBioinformaticsBases de dadesSYSTEMS MEDICINE0302 clinical medicineINFORMATICSCultural diversityHealth careGenetics(clinical)030212 general & internal medicineGenetics (clinical)media_commonGenetics & HeredityExabyteCHALLENGESMacrodadesCANCER3. Good healthAction planMolecular MedicineErratumLife Sciences & BiomedicineMedical GeneticsOpinion: Public health health care sciences & services [D22] [Human health sciences]MedicinaInformation DisseminationMECHANISMS03 medical and health sciencesFUTUREJournal ArticleGeneticsmedia_common.cataloged_instanceHumansKNOWLEDGEEuropean UnionEuropean unionMolecular BiologyMedicinsk genetik0604 GeneticsScience & Technologybusiness.industryInformation DisseminationHealth Plan Implementation1103 Clinical SciencesCAREData scienceData sharing030104 developmental biologyUNDIAGNOSED DISEASES NETWORKbusiness
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