6533b831fe1ef96bd1298d04
RESEARCH PRODUCT
Severe Chronic Allergic (and Related) Diseases: A Uniform Approach – A MeDALL – GA<sup>2</sup>LEN – ARIA Position Paper
J Rosado-pintoValérie SirouxValérie SirouxCynthia HohmannA. MazonOlivier VandenplasA. MohammadiM. P. OrruW. J. FokkensK-h. CarlsenG. KhayatJean BousquetRonald DahlGailen D. MarshallJan BrozekStefan WöhrlJ. RatomaharoNanshan ZhongPaulo Augusto Moreira CamargosMario Sánchez-borgesA. YorganciogluMariona PinartMika J. MäkeläA. BedbrookJordi SunyerPhilippe-jean BousquetG. PassalacquaRaphaëlle VarrasoG. S. OuedraogoIngrid TerreehorstG.w. CanonicaBianca BegheJohn WrightJosep M. AntóI. PinJ. RingF. KauffmannGerard H. KoppelmanWilliam K. DolenB. Koffi N'goranK. C. Lødrup CarlsenBrian J. LipworthAlkis TogiasA. Ben KhederRuby PawankarChristophe PisonDennis M. WilliamsOsman M. YusufEugene R. BleeckerHolger J. SchünemannM. Roman RodriguezAmiran GamkrelidzeElina ToskalaB. Hellquist-dahlSergio BoniniBénédicte JacqueminEleni FthenouE.h.d. BelMichael A. KalinerRuta DubakieneC. S. AngE. MelenIsabelle MomasElena Gimeno-santosKlaus F. RabeFerran BallesterBarbara RogalaAntonino RomanoStefano GuerraSam OddieE.d. BatemanH. DouaguiRenato T. SteinClaus BachertRobert M. NaclerioFernando D. MartinezTalant SooronbaevRudolf ValentaK. C. BergmannInger KullM. Morais-almeidaMarjan KerkhofNikolaos G. PapadopoulosJosep RocaL.-p. BouletL. T. LeDaniela PortaF. MartinK. S. BennoorAlfredo CesarioPiotr KunaWilliam W. BusseS. NaftiMübeccel AkdisDirkje S. PostmaPhil LiebermanDésirée LarenasAziz SheikhY. Z. ChenJ MullolT. DidiD. Y. WangMarta BenetPeter Schmid-grendelmeierDavid PriceTari HaahtelaDominique ValeyreF. E. R. SimonsI. Annesi-maesanoMagnus WickmanA. AndrianarisoaGiovanni ViegiPascal DemolyA. El-mezianeC. E. Baena-cagnaniC. E. Baena-cagnaniUlf DarsowS. PalkonenF. BerrissoulX. BasaganaR. Gerth Van WijkJ. O. B. HourihaneB. PigeariasA. L. BonerT. D. NyembueB. SamolinskiY. OkamotoW. CarrC. Van WeelMarek L. KowalskiChristopher E. BrightlingThomas KeilD. RezaguiD. J. CostaTodor PopovEli O. MeltzerIoana AgacheMarcus MaurerThomas B. CasaleT. BieberCharles AuffrayAntonella MuraroK. OhtaT. ZuberbierYousser MohammadHenriette A. SmitManolis KogevinasDermot RyanIris LaviMarc HumbertSakari ReitamoJ. JustMartijn C. NawijnM. BejiBassam MahboubF. MihaltanPeter H. HowarthAlvaro A. CruzCevdet OzdemirL. Namazova-baranovaY. TremblayM. E. ZernottiAdnan CustovicC. Bindslev JensenJoao FonsecaRobyn E O'hehirO. KalayciH. HaddadAndrew BushL. CoxMihaela ZidarnAnca-mirela ChiriacH. J. ZarJudith Garcia-aymerichG. K. ScaddingPeter J. SterkRichard G. RobertsMaria VassilakiP. PanznerP W Hellingssubject
medicine.medical_specialtybusiness.industryPublic healthImmunologymacromolecular substancesGeneral MedicineAtopic dermatitismedicine.disease3. Good health03 medical and health sciences0302 clinical medicine030228 respiratory systemDisease severityEpidemiologyImmunologymedicinePhysical therapyImmunology and AllergyPosition paperDisease process030212 general & internal medicineIntensive care medicinebusinessChronic urticariaAsthmadescription
Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-01-01 | International Archives of Allergy and Immunology |