0000000000745318

AUTHOR

Inés López

showing 2 related works from this author

Vinyl Fluorides: Competent Olefinic Counterparts in the Intramolecular Pauson–Khand Reaction

2019

Despite the great advances achieved in the Pauson-Khand reaction and the ever-increasing demand for fluorinated compounds, the use of vinyl fluorides as olefinic counterparts in the above-mentioned transformation had been completely overlooked. Herein, we describe, for the first time, the intramolecular Pauson-Khand reaction of enynes containing a vinyl fluoride moiety.

010405 organic chemistryChemistryPauson–Khand reactionOrganic Chemistry010402 general chemistry01 natural sciencesBiochemistry0104 chemical scienceschemistry.chemical_compoundIntramolecular forcePolymer chemistryMoietyPhysical and Theoretical ChemistryVinyl fluorideOrganic Letters
researchProduct

Metal-Free and User-Friendly Regioselective Hydroxyfluorination of Olefins

2018

A simple, user-friendly, metal-free protocol for the regioselective anti-Markovnikov hydrofluorination of olefins using readily available and inexpensive reagents has been developed. This new approach displays a broader scope than previously reported methodologies and has been applied to the late-stage fluorination of a complex molecule, giving rise to a fluorosteroid derivative. The stereochemistry of the process has also been studied in some detail.

User FriendlyHalogenationMolecular Structure010405 organic chemistryOrganic ChemistryRegioselectivityAlkenes010402 general chemistry01 natural sciencesBiochemistryCombinatorial chemistryArticle0104 chemical scienceschemistry.chemical_compoundchemistryMetal freeMetalsPhysical and Theoretical ChemistryDerivative (chemistry)
researchProduct