0000000000749449
AUTHOR
Maria Dolores Diaz
ChemInform Abstract: Synthesis and Reactivity of β-Amino α,β-Unsaturated Oxa- and Thiazolines.
Abstract A simple and efficient route to masked β-amino-α,β-unsaturated acids 3 by reaction of metalated oxa- and thiazolines with nitriles has been developed. The reactivity of 3 has also been explored.
<p>A randomized multicenter study comparing seawater washes and carmellose artificial tears eyedrops in the treatment of dry eye syndrome</p>
Purpose To investigate the safety and efficacy of sterile isotonic seawater washes vs standard treatment with carmellose artificial tears in dry eye syndrome (DES). Patients and methods This is a randomized multicenter prospective study with 12 weeks of follow-up. A group of patients with DES (N=60) were treated with seawater spray (Quinton®) five times daily, and another similar group (N=60) were treated with carmellose artificial tears eyedrops (Viscofresh® 0.5%) five times a day. The parameters studied and measured were as follows: Ocular Surface Disease Index questionnaire score, Schirmer I test (without anesthesia) score, tear osmolarity (TearLab®), tear breakup time, tear meniscus hei…
Synthesis and reactivity of β-amino-α,β-unsaturated oxa- and thiazolines
Abstract A simple and efficient route to masked β-amino-α,β-unsaturated acids 3 by reaction of metalated oxa- and thiazolines with nitriles has been developed. The reactivity of 3 has also been explored.
ChemInform Abstract: C-C versus C-N Annulation Reactions of 2-Alkyl-2-oxazolines and 2-Alkyl-2-thiazolines: A Simple Synthesis of Novel 3-Aminoindene, Phthalimidine, Pyrrolidine, and Piperidine Derivatives.
The effect of various aromatic and aliphatic dielectrophiles on the lithium azaenolates of 2-alkyl-2-oxazolines and 2-alkyl-2-thiazolines has been examined. This effect varies greatly, depending on the nature of the dielectrophile used. 3-Aminoindene (3) and 3-alkylidenephthalimidine (4−5) derivatives were formed as a result of the reactions with dielectrophiles derived from ortho-substituted benzonitriles. Similarly, 2-alkylidenepyrrolidine (7) and 2-alkylidenepiperidine (8) derivatives were obtained in high yields from 2-alkyl-2-oxazolines or 2-alkyl-2-thiazolines and aliphatic dielectrophiles derived from ω-haloalkyldiphenylacetonitrile. C−C versus C−N annulation reactions are discussed.
C−C versus C−N Annulation Reactions of 2-Alkyl-2-oxazolines and 2-Alkyl-2-thiazolines: A Simple Synthesis of Novel 3-Aminoindene, Phthalimidine, Pyrrolidine, and Piperidine Derivatives
The effect of various aromatic and aliphatic dielectrophiles on the lithium azaenolates of 2-alkyl-2-oxazolines and 2-alkyl-2-thiazolines has been examined. This effect varies greatly, depending on the nature of the dielectrophile used. 3-Aminoindene (3) and 3-alkylidenephthalimidine (4−5) derivatives were formed as a result of the reactions with dielectrophiles derived from ortho-substituted benzonitriles. Similarly, 2-alkylidenepyrrolidine (7) and 2-alkylidenepiperidine (8) derivatives were obtained in high yields from 2-alkyl-2-oxazolines or 2-alkyl-2-thiazolines and aliphatic dielectrophiles derived from ω-haloalkyldiphenylacetonitrile. C−C versus C−N annulation reactions are discussed.