6533b839fe1ef96bd12a6402

RESEARCH PRODUCT

Synthesis and reactivity of β-amino-α,β-unsaturated oxa- and thiazolines

José BarluengaSantos FusteroMaria Dolores DiazEnrique Aguilar

subject

chemistry.chemical_compoundAddition reactionchemistryNitrileOrganic ChemistryDrug DiscoveryOrganic chemistryReactivity (chemistry)AlkylationBiochemistryCombinatorial chemistryEnamine

description

Abstract A simple and efficient route to masked β-amino-α,β-unsaturated acids 3 by reaction of metalated oxa- and thiazolines with nitriles has been developed. The reactivity of 3 has also been explored.

https://doi.org/10.1016/0040-4039(92)80029-j