0000000000754749
AUTHOR
P. Kögel
Adjuvante Ganzkörper- akupunktur bei Depression
In order to examine the efficacy of whole body acupuncture additionally applied to drug treatment in depression, a single-blind placebo-controlled study with 70 inpatients administered to three different treatment groups has been carried out. All patients were pharmacologically treated with the tetracyclic antidepressant mianserin. The verum group (n = 22) received acupuncture at specific points considered to be effective in the treatment of depression. The placebo group (n = 24) was treated with acupuncture at non-specific locations and the control group (n = 24) received only pharmacological treatment. Acupuncture was applied three times a week over a period of four weeks. Psychopathology…
Electrophysiological evidence for an inverse benzodiazepine receptor agonist in panic disorder.
Abstract Inverse agonists of the GABA A receptor clearly decrease the amplitudes of the spontaneous EEG in the P-frequency range. Therefore, we tested the hypothesis that panic patients exhibit a reduction of the EEGs spectral power in the P-frequency band. Ten unmedicated patients with panic disorder and agoraphobia according to DSM-III-R criteria and 10 matched controls were investigated under baseline conditions, after hyperventilation and 30 min after hyperventilation. EEG recordings from the position P z and C z were performed under eyes closed conditions. At baseline conditions the patients suffering from panic disorder depicted a reduced P-power reaching statistically significance fo…
Analysis of sleep EEG microstructure in subchronic paroxetine treatment of healthy subjects
Paroxetine is a selective and potent serotonin reuptake inhibitor and its efficacy for the treatment of depression has been proven. Under acute and subchronical treatment regimens, disturbances of the regular sleep pattern are a reported side effect of the drug. The present study was therefore performed to investigate the impact of subchronic treatment with the selective serotonin reuptake inhibitor paroxetine on the microstructure of the sleep EEG. The study especially addressed the question of subchronic effects of paroxetine medication (30 mg/day) in eight healthy male volunteers in a double blind, placebo-controlled crossover design. Conventional sleep EEG parameters and a spectral powe…
Narkolepsie
Die Merkmale der Narkolepsie sind seit dem letzten Jahrhundert bekannt, die Tetrade der Zeichen wurde zuerst in den 50er Jahren beschrieben: ausgepragte Tagesmudigkeit, Kataplexien, Schlafparalyse und einschlaf- oder aufwachbezogene Halluzinationen. Polysomnographisch sind eine verkurzte Einschlaf- und REM-Latenz typisch, labordiagnostisch das menschliche Leukozyten-Antigen (HLA) in DQB1*0602 und DQA1*0102. Die exakte Pathophysiologie ist unbekannt, jedoch deuten neuere Studien auf Storungen im Orexin(Hypokretin)-Neurotransmittersystem hin. Man kennt etwa 1.500 Patienten in Deutschland mit Narkolepsie. Die Pravalenzrate in kaukasischen Populationen wird mit ca. 50/100.000 angegeben, so dass…