0000000000757009

AUTHOR

Kende Lőrincz

showing 2 related works from this author

Visualization of Keratin with Diffuse Reflectance and Autofluorescence Imaging and Nonlinear Optical Microscopy in a Rare Keratinopathic Ichthyosis.

2021

Keratins are one of the main fluorophores of the skin. Keratinization disorders can lead to alterations in the optical properties of the skin. We set out to investigate a rare form of keratinopathic ichthyosis caused by KRT1 mutation with two different optical imaging methods. We used a newly developed light emitting diode (LED) based device to analyze autofluorescence signal at 405 nm excitation and diffuse reflectance at 526 nm in vivo. Mean autofluorescence intensity of the hyperkeratotic palmar skin was markedly higher in comparison to the healthy control (162.35 vs. 51.14). To further assess the skin status, we examined samples from affected skin areas ex vivo by nonlinear optical micr…

MaleNonlinear Optical MicroscopyHyperkeratosisautofluorescencelcsh:Chemical technologyBiochemistryAnalytical Chemistry030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicineIn vivoKeratinmedicineHumanslcsh:TP1-1185Electrical and Electronic EngineeringInstrumentationkeratinSkinchemistry.chemical_classificationHyperkeratosis Epidermolyticintegumentary systemhyperkeratosisChemistryCommunicationOptical ImagingLEDnonlinear microscopyepidermolytic ichthyosismedicine.diseasediffuse reflectanceFluorescenceNonlinear optical microscopyAtomic and Molecular Physics and OpticsAutofluorescencemedicine.anatomical_structure030220 oncology & carcinogenesisChild Preschoolmultiphoton microscopyhistopathologyKeratinsKRT1EpidermisDiffuse reflectionBiomedical engineeringSensors (Basel, Switzerland)
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Quantitative Multispectral Imaging Differentiates Melanoma from Seborrheic Keratosis.

2021

Melanoma is a melanocytic tumor that is responsible for the most skin cancer-related deaths. By contrast, seborrheic keratosis (SK) is a very common benign lesion with a clinical picture that may resemble melanoma. We used a multispectral imaging device to distinguish these two entities, with the use of autofluorescence imaging with 405 nm and diffuse reflectance imaging with 525 and 660 narrow-band LED illumination. We analyzed intensity descriptors of the acquired images. These included ratios of intensity values of different channels, standard deviation and minimum/maximum values of intensity of the lesions. The pattern of the lesions was also assessed with the use of particle analysis. …

Seborrheic keratosisMedicine (General)diagnosisClinical BiochemistryMultispectral image01 natural sciencesArticleautofluorescence imaging010309 optics030207 dermatology & venereal diseases03 medical and health sciencesR5-9200302 clinical medicinediffuse reflectance imaging0103 physical sciencesmelanomaMedicineLed illuminationquantitative analysisbusiness.industryMelanomaLEDBenign lesionmedicine.diseaseIntensity (physics)Autofluorescencemelanoma; seborrheic keratosis; autofluorescence imaging; LED; dermoscopy; quantitative analysis; diffuse reflectance imaging; diagnosisseborrheic keratosisImaging techniquedermoscopybusinessNuclear medicineDiagnostics (Basel, Switzerland)
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