0000000000759018
AUTHOR
Bertrand Bardet
Decreasing dietary linoleic acid promotes long chain omega-3 fatty acid incorporation into rat retina and modifies gene expression
International audience; Age-related macular degeneration (AMD) may be partially prevented by dietary habits privileging the consumption of ω3 long chain polyunsaturated fatty acids (ω3s) while lowering linoleic acid (LA) intake. The present study aimed to document whether following these epidemiological guidelines would enrich the neurosensory retina and RPE with ω3s and modulate gene expression in the neurosensory retina. Rat progenitors and pups were fed with diets containing low or high LA, and low or high ω3s. After scotopic single flash and 8-Hz-Flicker electroretinography, rat pups were euthanized at adulthood. The fatty acid profile of the neurosensory retina, RPE, liver, adipose tis…
Decreasing the dietary intake of linoleic acid promotes the efficacy of dietary long chain omega-3 fatty acids to incorporate the rat retina and modifies gene expression
Decreasing the dietary intake of linoleic acid promotes the efficacy of dietary long chain omega-3 fatty acids to incorporate the rat retina and modifies gene expression. annual meeting of the association-for-research-in-vision-and-ophthalmology (ARVO)
Consequences of dietary omega-3 polyunsaturated fatty acid deficiency on retinal function and intraocular pressure in the rat
Purpose Omega-3 polyunsaturated fatty acids (ω3) are key components in nervous structures but their dietary intakes in the overall population are often below nutritional requirements. A chronic deficiency in ω3 is recognized to be associated with functional impairment of the retina. At the opposite, ω3 supplementation is associated with a reduced risk for AMD. The consequences of ω3 deficiency on other eye structures than the retina, such as ciliary bodies, are scarce. The purpose of our study was to compare the response of the retina and ciliary bodies to dietary ω3 deficiency in terms of fatty acid profile and eye functionality. Methods Two successive generations of Lewis rats (G1 and G2)…