0000000000774689

AUTHOR

Gustavo F. Bayón

showing 2 related works from this author

Longitudinal study of DNA methylation during the first 5 years of life

2016

[Background]: Early life epigenetic programming influences adult health outcomes. Moreover, DNA methylation levels have been found to change more rapidly during the first years of life. Our aim was the identification and characterization of the CpG sites that are modified with time during the first years of life. We hypothesize that these DNA methylation changes would lead to the detection of genes that might be epigenetically modulated by environmental factors during early childhood and which, if disturbed, might contribute to susceptibility to diseases later in life. [Methods]: The study of the DNA methylation pattern of 485577 CpG sites was performed on 30 blood samples from 15 subjects,…

0301 basic medicineLongitudinal studyADNCentromereBiologyGenomeGeneral Biochemistry Genetics and Molecular BiologyRepressive histone markBioconductor03 medical and health sciencesImmune systemCluster AnalysisHumansLongitudinal StudiesGeneGeneticsMedicine(all)Biochemistry Genetics and Molecular Biology(all)ResearchHistone markAdult health outcomeInfant NewbornInfantGeneral MedicineMethylationDNA MethylationTelomere030104 developmental biologyGene OntologyCpG siteChild PreschoolDNA methylationGene ontologySurrogate variable analysisCpG IslandsJournal of Translational Medicine
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DNA methylation patterns in newborns exposed to tobacco in utero

2015

[Background] Maternal smoking during pregnancy is a major risk factor for adverse health outcomes. The main objective of the study was to assess the impact of in utero tobacco exposure on DNA methylation in children born at term with appropriate weight at birth.

AdultEpigenomicsMothersPhysiologyBiologyGeneral Biochemistry Genetics and Molecular BiologyEpigenesis GeneticAdrenomedullinYoung Adultchemistry.chemical_compoundPregnancyRisk FactorsTobaccoCluster AnalysisHumansAdrenomedullin geneEpigeneticsNewbornsEpigenomicsMedicine(all)ImmunoassayDNA methylationBiochemistry Genetics and Molecular Biology(all)ResearchInfant NewbornGeneral MedicineMethylationFetal BloodGene Expression RegulationchemistryCpG siteMaternal ExposureIn uteroImmunologyDNA methylationCpG IslandsFemaleTobacco Smoke PollutionCotinineGenome-Wide Association StudyDNA hypomethylationJournal of Translational Medicine
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