0000000000791421

AUTHOR

Erik M. Shapiro

showing 2 related works from this author

Magnetic resonance imaging of the migration of neuronal precursors generated in the adult rodent brain

2006

Neural progenitor cells (NPCs) reside within the subventricular zone (SVZ) in rodents. These NPCs give rise to neural precursors in adults that migrate to the olfactory bulb (OB) along a well-defined pathway, the rostral migratory stream (RMS). Here we demonstrate that these NPCs can be labeled, in vivo, in adult rats with fluorescent, micron-sized iron oxide particles (MPIOs), and that magnetic resonance imaging (MRI) can detect migrating neural precursors carrying MPIOs along the RMS to the OB. Immunohistochemistry and electron microscopy indicated that particles were inside GFAP(+) neural progenitor cells in the SVZ, migrating PSA-NCAM(+) and Doublecortin(+) neural precursors within the …

Doublecortin ProteinRostral migratory streamCognitive NeuroscienceSubventricular zoneArticleCerebral VentriclesRats Sprague-DawleyCell MovementmedicineAnimalsProgenitor cellProgenitorNeuronsbiologyChemistryStem CellsBrainImmunohistochemistryMagnetic Resonance ImagingOlfactory BulbNeural stem cellRatsDoublecortinOlfactory bulbCell biologyMicroscopy Electronmedicine.anatomical_structurenervous systemNeurologybiology.proteinStem cellNeuroscienceFerrocyanidesNeuroImage
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Contributory presentations/posters

1999

0303 health sciencesbiologyGeneral Medicine010402 general chemistry01 natural sciencesHorseradish peroxidaseGeneral Biochemistry Genetics and Molecular Biology0104 chemical sciences03 medical and health sciencesBiochemistryManganese porphyrinbiology.proteinEnzyme reconstitutionGeneral Agricultural and Biological Sciences030304 developmental biologyJournal of Biosciences
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