0000000000814640
AUTHOR
Hervé Guillou
La combinaison de cartographie de signatures de sélection, de re-séquençage de génomes et d'analyses d'expression révèle PARK2 et JAG2 comme nouveaux genes candidats régulant l'adiposité
Very few causal genes have been identified by quantitative trait loci (QTLs) mapping because of the large size ofQTLs, and most of them were identified thanks to functional links already known with the targeted phenotype.Here we propose to combine selection signature detection, SNP annotation, and expression analyses to identifycausal genes underlying QTLs. As a model, we chose experimental chicken lines divergently selected for onlyone trait, the abdominal fat weight, in which several QTLs were previously mapped. Using a new haplotypebasedstatistics exploiting the very high SNP density generated through whole genome re-sequencing, we found129 significant selective sweeps. Most of the QTLs …
The first 40Ar-39Ar date from Oxfordian ammonite-calibrated volcanic layers (bentonites) as a tie-point for the Late Jurassic.
AbstractEight volcanic ash layers, linked to large explosive events caused by subduction-related volcanism from the Vardar Ocean back-arc, interbedded with marine limestones and cherts, have been identified in the Rosso Ammonitico Veronese Formation (northeastern Italy). The thickest ash layer, attributed to the Gregoryceras transversarium ammonite Biozone (Oxfordian Stage), yields a precise and reliable 40Ar–39Ar date of 156.1 ± 0.89 Ma, which is in better agreement with GTS2004 boundaries than with the current GTS2012. This first biostratigraphically well-constrained Oxfordian date is proposed as a new radiometric tie-point to improve the Geologic Time Scale for the Late Jurassic, where a…