0000000000855158

AUTHOR

Amador Garcia

showing 2 related works from this author

ChemInform Abstract: Selective Formal Transesterification of Fluorinated 2-(Trimethylsilyl)ethyl α-Imino Esters Mediated by TBAF.

2008

The scope of the transesterification reaction between β-fluorinated α-imino esters and various electrophiles in the presence of TBAF as fluorine source is described. The reaction is highly selective for alkyl iodides, bromides, and mesylates, while alkyl chlorides react at a significantly slower rate and tosylates do not react under the reaction conditions. This methodology represents a simple and useful alternative for the preparation of a wide variety of fluorinated α-imino esters.

Reaction conditionschemistry.chemical_classificationTrimethylsilylchemistry.chemical_elementGeneral MedicineTransesterificationHighly selectivechemistry.chemical_compoundchemistryElectrophileFluorineOrganic chemistryheterocyclic compoundsTransesterification reactionAlkylChemInform
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Selective Formal Transesterification of Fluorinated 2-(Trimethylsilyl)ethyl α-Imino Esters Mediated by TBAF

2008

The scope of the transesterification reaction between beta-fluorinated alpha-imino esters and various electrophiles in the presence of TBAF as fluorine source is described. The reaction is highly selective for alkyl iodides, bromides, and mesylates, while alkyl chlorides react at a significantly slower rate and tosylates do not react under the reaction conditions. This methodology represents a simple and useful alternative for the preparation of a wide variety of fluorinated alpha-imino esters.

chemistry.chemical_classificationTrimethylsilylChemistryOrganic Chemistrychemistry.chemical_elementTransesterificationChemical synthesisReaction ratechemistry.chemical_compoundElectrophileFluorineOrganic chemistryheterocyclic compoundsSelectivityAlkylThe Journal of Organic Chemistry
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