6533b837fe1ef96bd12a26ca
RESEARCH PRODUCT
ChemInform Abstract: Selective Formal Transesterification of Fluorinated 2-(Trimethylsilyl)ethyl α-Imino Esters Mediated by TBAF.
Silvia CatalanSantos FusteroMaría Sánchez-rosellóAmador GarciaVanessa RodrigoCarlos Del Pozosubject
Reaction conditionschemistry.chemical_classificationTrimethylsilylchemistry.chemical_elementGeneral MedicineTransesterificationHighly selectivechemistry.chemical_compoundchemistryElectrophileFluorineOrganic chemistryheterocyclic compoundsTransesterification reactionAlkyldescription
The scope of the transesterification reaction between β-fluorinated α-imino esters and various electrophiles in the presence of TBAF as fluorine source is described. The reaction is highly selective for alkyl iodides, bromides, and mesylates, while alkyl chlorides react at a significantly slower rate and tosylates do not react under the reaction conditions. This methodology represents a simple and useful alternative for the preparation of a wide variety of fluorinated α-imino esters.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-11-25 | ChemInform |