0000000000855587

AUTHOR

Catarina Brito

showing 2 related works from this author

Conversion of Nonproliferating Astrocytes into Neurogenic Neural Stem Cells: Control by FGF2 and Interferon-gamma

2016

Abstract Conversion of astrocytes to neurons, via de-differentiation to neural stem cells (NSC), may be a new approach to treat neurodegenerative diseases and brain injuries. The signaling factors affecting such a cell conversion are poorly understood, and they are hard to identify in complex disease models or conventional cell cultures. To address this question, we developed a serum-free, strictly controlled culture system of pure and homogeneous “astrocytes generated from murine embryonic stem cells (ESC).” These stem cell derived astrocytes (mAGES), as well as standard primary astrocytes resumed proliferation upon addition of FGF. The signaling of FGF receptor tyrosine kinase converted G…

0301 basic medicineCell signalingNeurogenesisBiologyInterferon-gammaMice03 medical and health sciences0302 clinical medicineNeural Stem CellsNeurosphereddc:570medicineAnimalsCell ProliferationEpidermal Growth FactorMultipotent Stem CellsCell CycleNeurogenesisMouse Embryonic Stem CellsCell BiologyAnatomyCell DedifferentiationEmbryonic stem cellNeural stem cellCell biologyNeuroepithelial cell030104 developmental biologymedicine.anatomical_structureGene Expression RegulationAstrocytesMolecular MedicineFibroblast Growth Factor 2Stem cell030217 neurology & neurosurgerySignal TransductionDevelopmental BiologyAstrocyte
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Mind the gap—deficits in our knowledge of aspects impacting the bioavailability of phytochemicals and their metabolites—a position paper focusing on …

2015

This is an open access article under the terms of the Creative Commons Attribution-Non-Commercial-NoDerivs Licence.-- et al.

Food processingColonFood HandlingMetabolitePhytochemicalsBiological AvailabilityReviewsReviewPharmacologyBiologymedicine.disease_causeGastrointestinal epitheliumchemistry.chemical_compoundSDG 3 - Good Health and Well-beingBiotransformationsIntestine SmallmedicineHumansTissue DistributionCarotenoidBiotransformationchemistry.chemical_classificationMicrobiotaPolyphenolsCarotenoidsGastrointestinal MicrobiomeBioavailabilityTransportersIntestinal AbsorptionSolubilityPhytochemicalBiochemistrychemistryPolyphenol/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingEffluxOxidative stressMixed dietFood ScienceBiotechnologyMolecular Nutrition & Food Research
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