0000000000885932
AUTHOR
Anna Rossi
showing 14 related works from this author
Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute resp…
2022
Contains fulltext : 252214.pdf (Publisher’s version ) (Open Access) BACKGROUND: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies. METHODS: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to defi…
Supernova bounds on resonant active-sterile neutrino conversions
1997
We discuss the effects of resonant $\nu_e \to \nu_s$ and $\bar{\nu}_e \to \bar{\nu}_s$ ($\nu_s$ is a sterile neutrino) conversions in the dense medium of a supernova. In particular, we assume the sterile neutrino $\nu_s$ to be in the hot dark matter few eV mass range. The implications of such a scenario for the supernova shock re-heating, the detected $\bar\nu_e$ signal from SN1987A and for the r-process nucleosynthesis hypothesis are analysed in some detail. The resulting constraints on mixing and mass difference for the $\nu_e-\nu_s$ system are derived. There is also an allowed region in the neutrino parameter space for which the r-process nucleosynthesis can be enhanced.
Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG …
2017
Background Little information is available about the geo-economic variations in demographics, management, and outcomes of patients with acute respiratory distress syndrome (ARDS). We aimed to characterise the effect of these geo-economic variations in patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE). Methods LUNG SAFE was done during 4 consecutive weeks in winter, 2014, in a convenience sample of 459 intensive-care units in 50 countries across six continents. Inclusion criteria were admission to a participating intensive-care unit (including transfers) within the enrolment window and receipt of invasive or non…
Resonant conversion of massless neutrinos in supernovae
1996
It has been noted for a long time that, in some circumstances, {\sl massless} neutrinos may be {\sl mixed} in the leptonic charged current. Conventional neutrino oscillation searches in vacuum are insensitive to this mixing. We discuss the effects of resonant massless-neutrino conversions in the dense medium of a supernova. In particular, we show how the detected $\bar\nu_e$ energy spectra from SN1987a and the supernova $r$-process nucleosynthesis may be used to provide very stringent constraints on the mixing of {\sl massless} neutrinos.
Supernova Bounds on Supersymmetric $R$-parity Violating Interactions
1996
We re-examine resonant massless-neutrino conversions in a dense medium induced by flavour changing neutral current (FCNC) interactions. We show how the observed $\bar\nu_e$ energy spectra from SN1987a and the supernova $r$-process nucleosynthesis provide constraints on supersymmetric models with $R$ parity violation, which are much more stringent than those obtained from the laboratory. We also suggest that resonant massless-neutrino conversions may play a positive role in supernova shock reheating. Finally, we examine the constraints on explicit $R$-parity-violating FCNCs in the presence of non-zero neutrino masses in the eV range, as indicated by present hot dark matter observations.
The effect of random matter density perturbations on the MSW solution to the solar neutrino problem
1996
We consider the implications of solar matter density random noise upon resonant neutrino conversion. The evolution equation describing MSW-like conversion is derived in the framework of the Schr\"odinger approach. We study quantitatively their effect upon both large and small mixing angle MSW solutions to the solar neutrino problem. This is carried out both for the active-active $\nu_e \ra \nu_{\mu,\tau}$ as well as active-sterile $\nu_e \ra \nu_s$ conversion channels. We find that the small mixing MSW solution is much more stable (especially in $\Delta m^2$) than the large mixing solution. The possible existence of solar matter density noise at the few percent level could be tested at futu…
Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study
2022
Supported by Centro de Investigación Biomédica en Red (CIBER)‑Enfermedades respiratorias, Madrid, Spain (CB17/06/00021) and Fundación para el Fomento en Asturias de la Investigación Científica aplicada y la tecnología (FICYT, AYUD2021/52014). RRG is the recipient of a grant from Instituto de Salud Carlos III, Madrid, Spain (CM20/00083).
Borexino as a test of solar matter density fluctuations
1997
This talk summarizes some results of our recent work focusing on the possibility to test solar matter density fluctuations by the future Borexino experiment.
Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: Insights from the LUNG SAFE study
2020
Abstract Background Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence o…
Bounds on sterile neutrino mixing for cosmologically interesting mass range
1997
This talk summarizes our recent work which studied the impact of resonant $\nu_e \to\nu_s$ and $\bar{\nu}_e\to\bar{\nu}_s$ ($\nu_s$ is a sterile neutrino) conversions on supernova physics, under the assumption that the mass of the sterile state is in the few eV -cosmologically significant range.
Immunocompromised patients with acute respiratory distress syndrome: Secondary analysis of the LUNG SAFE database
2018
Background: The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiog…
Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective …
2022
Item does not contain fulltext BACKGROUND: Two acute respiratory distress syndrome (ARDS) subphenotypes (hyperinflammatory and hypoinflammatory) with distinct clinical and biological features and differential treatment responses have been identified using latent class analysis (LCA) in seven individual cohorts. To facilitate bedside identification of subphenotypes, clinical classifier models using readily available clinical variables have been described in four randomised controlled trials. We aimed to assess the performance of these models in observational cohorts of ARDS. METHODS: In this observational, multicohort, retrospective study, we validated two machine-learning clinical classifie…
"Se ei oo mulle pelkkä koulutus" : Life coach -koulutus kokonaisvaltaisen oppimisen ja henkilökohtaisen kehityksen voimaannuttavana mahdollistajana
2017
Tämän laadullisen tutkimuksen tarkoituksena oli selvittää, mitä vajaan vuoden mittaiseen life coach -koulutukseen osallistuvat aikuisopiskelijat kokivat koulutusjakson aikana, millaista oppimista koulutuksen aikana tapahtui sekä miten koulutuksen vaikutukset näkyivät opiskelijoiden arjessa. Tutkimuksen teon aikana tutkimuksen fokus tarkentui, ja keskeiseksi nousivat kokemuksellisen oppimisen merkitys sekä opiskelijoiden koulutusvuoden aikana kokema henkilökohtainen oppimis- ja kasvuprosessi. Tutkimuksen taustateoriana on fenomenologis-hermeneuttinen lähestymis- tapa, jonka pohjalta tutkimusmenetelmäksi valikoitui haastattelututkimus. Aineistonkeruu toteutettiin avoimien haastatteluiden muod…
Outcomes of Patients Presenting with Mild Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study
2019
Editor's Perspective What We Already Know about This Topic Hospital mortality in acute respiratory distress syndrome is approximately 40%, but mortality and trajectory in "mild" acute respiratory distress syndrome (classified only since 2012) are unknown, and many cases are not detected What This Article Tells Us That Is New Approximately 80% of cases of mild acute respiratory distress syndrome persist or worsen in the first week; in all cases, the mortality is substantial (30%) and is higher (37%) in those in whom the acute respiratory distress syndrome progresses Background: Patients with initial mild acute respiratory distress syndrome are often underrecognized and mistakenly considered …