Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries

© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index to support local elective surgical system strengthening and address growing backlogs. Methods: First, we performed an international consultation through a four-stage consensus process to develop a multidomain index for hospital-level assess…

Towards the identification and quantification of candidate metabolites of tebuconazole fungicide

International audience; Tebuconazole belongs to the family of triazole fungicides, used for crop protection and human health applications. In the environment, the dissipation of the parent molecule leads to the formation of metabolites that are of unknown identity or toxicity. In order to identify and determine the putative identity of those metabolites and their po- tential toxicity, a quadrupole time-of-flight (Q-TOF) approach is often used. Q-SAR approaches help to predict their toxicity by comparing them to a known database of molecules with known properties. All together the information on the candidate by-products may help to select relevant sub-set of metabolites for further quantifi…

Evidence for the interest of suspect screening metabolomics to identify known and unkown pesticide metabolites in soil

Assessment of nitrate contamination risk: The Italian experience

16 páginas, 19 figuras, 10 tablas.-- El PDF es el manuscrito aceptado para su publicación.-- et al.

Lab-to-field experimental approach to study the dissipation, metabolism, and soil microbial ecotoxicity of isoproturon, tebuconazole, and chlorpyrifos

International audience

SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study

SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 da…

New approach to identify and categorize pesticide metabolites in soil combining suspect screening metabolomics with in silico molecular typology. 5th International Conference on Environmental Pollution and Remediation (ICEPR)

New approach to identify and categorize pesticide metabolites in soil combining suspect screening metabolomics with in silico molecular typology. 5th International Conference on Environmental Pollution and Remediation (ICEPR). 5th International Conference on Environmental Pollution and Remediation (ICEPR)

Do we need a new regulatory framework for assessing the soil microbial ecotoxicity of pesticides?

International audience

Effects of different progesterone levels on reproductive outcomes in assisted reproductive technologies: from molecular basis to treatment strategies

Purpose: The aim of this narrative review is to offer an overview about the role of progesterone levels on pregnancy outcome in patients undergoing assisted reproductive technologies (ARTs). Methods: A detailed computerized search of the literature was performed in the main electronic databases (MEDLINE, EMBASE, Web of Science) to determine the importance of elevated progesterone levels at different stages of the cycle for pregnancy rates in the in vitro fertilization (IVF) cycle. Our review also provides information on the differences between elevated progesterone levels and their interpretation in normal and in poorly responding women. Results: After careful evaluation, our search strateg…

Evaluation of the environmental fate and ecotoxicological impact of the pesticide chlorpyrifos in soil for improvement of its environmental risk assessment

EABIOMEUBINRA; Pesticides protect crops from various pests but can also harm nontarget organisms. To minimize risks for the environment and human health, a huge amount of studies are carried out and evaluated during the authorization process of each pesticide. However, the prediction of the environmental fate and ecotoxicological impact of a pesticide remains difficult. Several 100 formerly used pesticides are now banned because unexpected risks emerged decades after their authorization. Risk assessment documents of the organophosphate insecticide chlorpyrifos (CHL) particularly lack information about its degradation and potential transformation products in soil, and its impact on non-targe…

Learning Laparoscopic Radical Hysterectomy: Are We Facing an Emerging Situation?

Despite wide screening campaigns and early detection, cervical cancer remains the fourth most common cancer among women. Radical hysterectomy, whether by open, laparoscopic or by robotic-assisted techniques, is the mainstay treatment. However, for adequate surgical results and good oncological prognosis, a gynecological surgeon should be trained to perform those procedures. The learning curve of radical hysterectomy, especially by laparoscopy, is influenced by several factors. The LACC trial, the decrease in cervical cancer incidence and radical hysterectomy procedures have widely reduced the learning curve for surgeons. This article mainly discusses the learning curve of laparoscopic radic…

A tiered-based approach to study the dissipation and adsorption of isoproturon, tebuconazole and chlorpyrifos in soil

The Prognostic Characteristics and Recurrence Patterns of High Grade Endometrioid Endometrial Cancer: A Large Retrospective Analysis of a Tertiary Center

High grade endometrioid endometrial cancer (HGEEC) is a heterogeneous group of tumors with unclear prognostic features. The aim of the present study is to evaluate the independent risk factors for recurrence and mortality and to describe the recurrence patterns of HGEEC. Ninety-six consecutive cases of HGEEC treated with primary surgery in a single Tertiary Center were retrospectively reviewed. Clinicopathological and treatment details were recorded, and all patients were closely followed up. Disease-free, overall and cancer-specific survival rates were 83.8%, 77.8% and 83.6%, respectively. Cervical stromal involvement was independently related to recurrence (HR = 25.67; 95%CI 2.95–223.30; …

Fate and metabolism of the herbicide isoproturon in soil microcosms and its impact on soil microbial communities using advanced molecular tools

International audience

Pourquoi faut-il se préoccuper de la toxicité des pesticides pour les microorganismes du sol ?

EABIOmE INRA; Pourquoi faut-il se préoccuper de la toxicité des pesticides pour les microorganismes du sol ?

Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic

Objective Coronavirus disease 2019 (COVID-19) outbreak has correlated with the disruption of screening activities and diagnostic assessments. Endometrial cancer (EC) is one of the most common gynecological malignancies and it is often detected at an early stage, because it frequently produces symptoms. Here, we aim to investigate the impact of COVID-19 outbreak on patterns of presentation and treatment of EC patients. Methods This is a retrospective study involving 54 centers in Italy. We evaluated patterns of presentation and treatment of EC patients before (period 1: March 1, 2019 to February 29, 2020) and during (period 2: April 1, 2020 to March 31, 2021) the COVID-19 outbreak. Results M…