0000000000901477
AUTHOR
Rafael Gómez De Diego
Effect of topical application of melatonin on serum levels of C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in patients with type 1 or type 2 diabetes and periodontal disease
Background: The present clinical trial study was designed to assess the effect of topical application of melatonin on serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and C-reactive protein (CRP) in patients with diabetes and periodontal disease in comparison with healthy controls. Material and Methods: Serum levels of TNF-α and IL-6 were measured by enzyme-linked immunosorbent assay and CRP by nephelometry by using the proper commercial kits in 30 patients with diabetes and periodontal disease, and also in a control group of 30 healthy subjects. Periodontograms were performed using the Florida Probe®. Patients with diabetes were treated with a topical application o…
Neuropathic pain associated with mucocele in the maxillary sinus
Mucocele in the paranasal sinuses consists of a clinically unpainful, pseudocystic lesion that may be confused with cysts with mucosal accumulation due to an obstruction of a seromucinous gland or with other lesions displaying expansive masses in the maxillary sinuses. Histologically, mucocele consists of an accumulation of seromucosal secretion lined by epithelium. It is an infrequent pathology, whose treatment has evolved favourably to a considerable extent over the past decades. Here we report a case of mucocele located in a paranasal sinus associated with a syndrome of odontalgic neuritic pain. After the collection of complementary radiological evidence, antrostomic surgical treatment w…
Gingival hyperplasia as an early manifestation of acute myeloid leukemia. A retrospective review
Background We study the prevalence of acute myeloid leukemia (AML) among patients with severe gingival enlargement. Material and Methods We retrospective reviewed the clinical records of patients with severe gingival enlargement, between 2011 and 2018. The Saxer and Mühlemann index were used to measure inflammation and gingival bleeding. The degree of dental mobility was measured by the Nyman and Lindhe technique. Results A correlation analysis was carried out to test whether there were any associations among the different variables. In the sample of 117 patients the mean gingival bleeding index was ≥3 and the degree of dental mobility ≥2.3. 1.7% of patients, with severe gingival hyperplasi…
State anxiety and depression as factors modulating and influencing postoperative pain in dental implant surgery. A prospective clinical survey
Objetives: To determine whether preoperative state anxiety and depression modulate or influence objective and subjective postoperative pain following dental implant insertion. Study Design: Prospective, clinical study with 7-day follow-up of a sample of 105 subjects who preoperatively completed the state anxiety questionnaire (STAI-E) and Beck Depression Inventory (BDI) and postoperatively, at 2 and 7 days, recorded objective pain with the Semmes-Weinstein mechanical esthesiometer (SW test) and subjective pain with the Visual Analog Scale (VAS). Results: 85.6% and 81.5% of patients, respectively, recorded no signs of state anxiety or depression. The correlation between anxiety and depressio…
Indications and contraindications of dental implants in medically compromised patients: update.
The aim of this study was to review the current scientific literature in order to analyse the indications and contraindications of dental implants in medically compromised patients. A reference research was carried out on PubMed using the key words “implant” AND (oral OR dental) AND (systemic disease OR medically compromised), in articles published between 1993 and 2013. The inclusion criteria were the following: clinical studies in which, at least, 10 patients were treated, consensus articles, reviewed articles and meta-analysis performed in humans treated with dental implants, and which included the disease diagnosis. A total of 64 articles were found, from which 16 met the inclusion crit…
Prosthetic rehabilitation of an edentulous cleft palate using a denture with a palatal obturator: a clinical report
A cleft palate is a genetic disorder that occurs when an oro-nasal communication is present between the palate and the base of the nose. During pregnancy, the maxillary is not completely merged, and the defect is only seen at birth. Possible causes are hormonal imbalances, nutritional deficiencies, infections, radiation during pregnancy, alcohol or cigarette consumption, the ingestion of other teratogenic substances by the mother, and heredity. The resulting defect requires corrective surgery. In the case of a cleft palate, surgery is postponed until after the first year of life to avoid disturbing the normal development of speech and the risk of aspiration of food, which causes infections …
Effect of gingival application of melatonin on alkaline and acid phosphatase, osteopontin and osteocalcin in patients with diabetes and periodontal disease
Objectives: To assess the effect of topical application of melatonin to the gingiva on salivary fluid concentrations of acid phosphatase, alkaline phosphatase, osteopontin, and osteocalcin. Study Design: Cross-sectional study of 30 patients with diabetes and periodontal disease and 30 healthy subjects. Diabetic patients were treated with topical application of melatonin (1% orabase cream formula) once daily for 20 days and controls with a placebo formulation. Results: Before treatment with melatonin, diabetic patients showed significantly higher mean salivary levels of alkaline and acid phosphatase, osteopontin and osteocalcin than healthy subjects (P < 0.01). After treatment with melatonin…