Early age of onset, brain morphological changes and non-consistent motor asymmetry in schizophrenic patients.

Previous data suggest abnormalities in the consistence of motor dominance in schizophrenia (e.g. mixed-handedness, poor correlation between hand, eye and foot preferences and an increase of hand-eye crossed dominance). The aim of this work is to examine the clinical significance of hand-eye and hand-foot crossed dominance in a sample of 61 right-handed schizophrenic patients. The application of multivariate analysis revealed that 23 right-handed and non-right-eyed patients (crossed hand-eye dominant group) had a significant earlier clinical onset and smaller brain size, global and frontal area, than 38 right-handed and right-eyed schizophrenics (consistent hand-eye dominance group). These f…

Fe de errores de «Relación entre insight, violencia y diagnóstico en pacientes con psicosis»

Using gene expression and systems biology to interrogate auditory hallucinations in schizophrenic patients

Schizophrenia is a severe mental disorder affecting around 1% of the opulation. This disease presents a complex aetiology that has not been completely unveiled yet. Auditory hallucinations are a very significant and disruptive symptom of schizophrenia affecting between 60% and 80% of schizophrenic patients. In this paper we have used a network-based transcriptomic analysis aiming to identify differences in gene expression between schizophrenic patients with and without auditory hallucinations. Gene expression data from blood samples drained from 30 schizophrenia patients were generated using Affymetrix Human Gene 2.0 ST Genechips. Affymetrix Expression console was used for normalization and…

Relación entre insight, violencia y diagnóstico en pacientes con psicosis

Resumen Introduccion En pacientes con trastornos psiquiatricos el deficit en la capacidad de introspeccion o insight es frecuentemente un problema clinico importante, pero ha sido pocas veces objeto de estudio formal. Los pacientes psicoticos con buen insight suelen cumplir mejor las pautas de medicacion siendo un factor de buen pronostico y muestran menor hostilidad. Con este estudio se pretende valorar si existe una relacion entre el grado de hostilidad del paciente y la conciencia de enfermedad ademas de analizar si el grado de conciencia de enfermedad varia segun el diagnostico del paciente (esquizofrenia vs. trastorno bipolar). Metodologia Se estudiaron en 168 pacientes psicoticos (ent…

Erratum to “Relationship between insight, violence and diagnoses in psychotic patients”

The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI): Incidence and First-Episode Case-Control Programme. Soc Psychiatry Psychiatr Epidemiol

Purpose: The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study contains an unparalleled wealth of comprehensive data that allows for testing hypotheses about (1) variations in incidence within and between countries, including by urbanicity and minority ethnic groups; and (2) the role of multiple environmental and genetic risk factors, and their interactions, in the development of psychotic disorders. Methods: Between 2010 and 2015, we identified 2774 incident cases of psychotic disorders during 12.9 million person-years at risk, across 17 sites in 6 countries (UK, The Netherlands, France, Spain, Italy, and Brazil). Of the 2774 incident…

Psicothema

Resumen tomado de la publicación Es fundamental un mayor conocimiento del temperamento infantil puesto que puede predecir el desarrollo de psicopatología posterior. Los cuestionarios adaptados a población infantil española cubren un rango de edad limitado. La escala más utilizada para estudios de genética del temperamento infantil es la Emotionality Activity and Sociability Temperament Survey (EAS). El principal objetivo de este estudio es realizar la versión española del EAS y comprobar sus propiedades psicométricas. Se administró la versión española del cuestionario a una muestra de 229 madres y sus hijos a los 18 y 42 meses. Se ha encontrado una fiabilidad comparable a la obtenida en pob…

Inducción de manía por inhibidores de la colinesterasa: evidencia empírica a través de datos observacionales

Resumen Objetivos Evaluar si los inhibidores de la colinesterasa pueden inducir mania, y determinar si este efecto puede estar relacionado con estados u otras caracteristicas previas de los pacientes. Metodo Se realizo una revision sistematica, incluyendo articulos publicados en ISI Web of Knowledge y PubMed, desde enero de 1990 a marzo de 2018, siguiendo criterios PRISMA. Resultados De 326 estudios identificados, se incluyeron en la revision 16. En los casos comunicados hay una correlacion entre la introduccion de un inhibidor de la colinesterasa y la aparicion de un episodio maniaco/hipomaniaco. El riesgo parece ser mayor si el paciente tiene antecedentes de trastorno afectivo y si esta t…

Relationship between insight, violence and diagnoses in psychotic patients

Abstract Introduction Lack of insight is a common clinical problem in psychiatric patients, but few times has been properly studied until recently. Patients with good insight tend to show a better treatment adherence with a better prognosis and show less hostility. This study aims to investigate whether there is a relationship between the hostility degree and insight or not and to analyse if there are insight quantitative differences between the patients regarding their diagnoses. Method One hundred and sixty-eight psychotic patients were studied (including 86 patients with schizophrenia and 43 with bipolar disorder). PANNS P7 (hostility) item and G14 (poor impulse control) were analysed in…