6533b7dafe1ef96bd126edd9
RESEARCH PRODUCT
Early age of onset, brain morphological changes and non-consistent motor asymmetry in schizophrenic patients.
Julio Sanjuán AriasManuel Gómez-beneytoCarmen Leal CercósRafael Tabarés Seisdedossubject
AdultMalePsychosismedicine.medical_specialtyMultivariate analysisgenetic structuresCentral nervous systemAudiologyNeuropsychological TestsFunctional LateralityDevelopmental psychologymedicineHumansClinical significanceBiological PsychiatryDominance (genetics)Retrospective StudiesAge FactorsBrainmedicine.diseaseeye diseasesPsychiatry and Mental healthmedicine.anatomical_structureMotor SkillsBrain sizeLateralitySchizophreniaFemalesense organsAge of onsetPsychomotor DisordersPsychologydescription
Previous data suggest abnormalities in the consistence of motor dominance in schizophrenia (e.g. mixed-handedness, poor correlation between hand, eye and foot preferences and an increase of hand-eye crossed dominance). The aim of this work is to examine the clinical significance of hand-eye and hand-foot crossed dominance in a sample of 61 right-handed schizophrenic patients. The application of multivariate analysis revealed that 23 right-handed and non-right-eyed patients (crossed hand-eye dominant group) had a significant earlier clinical onset and smaller brain size, global and frontal area, than 38 right-handed and right-eyed schizophrenics (consistent hand-eye dominance group). These findings are discussed within the context of neurodevelopmental disorders.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1999-06-01 | Schizophrenia research |