Salivary Biomarkers for Oral Squamous Cell Carcinoma Diagnosis and Follow-Up: Current Status and Perspectives.

2019

Oral cancer is the sixth most common cancer type in the world, and 90% of it is represented by oral squamous cell carcinoma (OSCC). Despite progress in preventive and therapeutic strategies, delay in OSCC diagnosis remains one of the major causes of high morbidity and mortality; indeed the majority of OSCC has been lately identified in the advanced clinical stage (i.e., III or IV). Moreover, after primary treatment, recurrences and/or metastases are found in more than half of the patients (80% of cases within the first 2 years) and the 5-year survival rate is still lower than 50%, resulting in a serious issue for public health. Currently, histological investigation represents the “gold stan…

The effects of an amine fluoride/stannous fluoride and an antimicrobial host protein mouthrinse on supragingival plaque regrowth.

2004

BACKGROUND: Chlorhexidine (CHX)-containing mouthrinses are recommended as adjuncts to mechanical oral hygiene. The problem associated with side effects, however, has stimulated the search for alternative antiplaque agents. The aim of this study was to investigate the plaque inhibitory effects of two mouthrinses containing amine fluoride/stannous fluoride (ASF) and antimicrobial host proteins (lactoperoxidase, lysozyme and lactoferrin; LLL), respectively. METHODS: The study was an observer-masked, randomized 4x4 Latin square cross-over design balanced for carryover effects, involving 12 healthy volunteers in a 4-day plaque regrowth model. A 0.12% CHX mouthrinse and a saline solution served a…

Effect of hormone replacement therapy (HRT) on periodontal status of postmenopausal women.

2011

Summary Background The risks/benefits balance of hormone replacement therapy (HRT) is controversial. The aim of this study was to assess the periodontal status of a postmenopausal women group receiving HRT and to determine the effects of HRT on clinical measures of periodontal disease. Material/Methods Ninety-one postmenopausal women, 52 taking HRT (HRT+) and 39 not taking HRT (HRT−), completed the study. Clinical parameters measured included visible supragingival plaque, probing pocket depth (PD) and clinical attachment level (CAL). Gingival status was recorded as gingival bleeding on probing (BOP). Previous oral contraceptive use and current and past smoking status were also assessed. Res…

The effects of antimicrobial sprays and mouthrinses on supragingival plaque regrowth: a comparative study.

2006

BACKGROUND: Due to the side effects of chlorhexidine digluconate (CHX) mouthrinsing, a spray has been proposed as an alternative method of CHX delivery to the oral cavity. The aim of this study was to investigate the plaque inhibitory effects of CHX, cetylpyridinium chloride (CPC), and triclosan (TRN) delivered by sprays and mouthrinses. METHODS: The study was an observer-masked, randomized cross-over design balanced for carryover effects, involving 15 healthy volunteers in a 4-day plaque regrowth model. Products being tested (0.2% CHX, 0.12% CHX, 0.05% CPC, and 0.03% TRN) were used both as sprays and mouthrinses. A saline solution served as a negative control. On day 1, subjects received p…

Genotyping and antifungal susceptibility of human subgingival Candida albicans isolates.

2002

Subgingival colonization by Candida albicans has been described in human immunodeficiency virus (HIV)-infected individuals, but subgingival isolates have scarcely been characterized, particularly with respect to genotype and antifungal susceptibility. A series of 29 subgingival strains of C. albicans isolated from nine HIV-infected individuals was typed by electrophoretic karyotyping and tested for susceptibility to fluconazole, itraconazole, the new investigational triazole posaconazole and amphotericin B. DNA typing showed genetic heterogeneity within subgingival isolates, as almost every individual harbored his/her own specific isolate. Genetic identity was usually demonstrated within or…

In vitro antifungal properties of mouthrinses containing antimicrobial agents

1997

The purpose of this study was to investigate the in vitro antifungal properties of seven commercial mouthrinses containing antimicrobial agents. These included cetylpyridinium chloride (CPC), chlorhexidine digluconate (CHX), hexetidine (HEX), sanguinarine (SNG), and triclosan (TRN). The minimum fungicidal concentration (MFC) against six species of yeasts was determined by a broth macrodilution method. The kill-time of mouthrinses at half the concentration of the commercial formulations was also determined. MFCs were achieved with each mouthrinse, except the SNG-containing mouthrinse, against all the organisms being tested. However, the CPC-containing mouthrinse appeared more active than the…

Pigmentazioni dentarie da clorexidina: una revisione critica

2020

OBIETTIVI Obiettivo di questo lavoro è proporre una revisione critica della letteratura sulle pigmentazioni orali indotte dalla clorexidina, in particolare sul meccanismo di formazione delle pigmentazioni, sulla loro prevalenza, sui fattori che ne influenzano l’insorgenza e la gravità e sull’efficacia clinica del sistema antipigmentazione a base di sodio metabisolfito e di acido ascorbico (ADS). MATERIALI E METODI È stata effettuata una ricerca bibliografica utilizzando in combinazione le seguenti parole chiave: Chlorhexidine, Mouthwash, Staining, Anti-Discoloration System, Gingivitis, Plaque. Sono stati presi in considerazione articoli scientifici e revisioni della letteratura in inglese, …

Probiotics Can Cure Oral Aphthous-Like Ulcers in Inflammatory Bowel Disease Patients: A Review of the Literature and a Working Hypothesis

2019

Dysbiosis has been associated with the onset of several chronic autoimmune or inflammatory pathologies (e.g., inflammatory bowel diseases—IBD), because of its primary role in the establishment of a chronic inflammatory process leading to tissue damage. Inflammatory bowel diseases can even involve areas far away from the gut, such as the extraintestinal manifestations involving the oral cavity with the onset of aphthous-like ulcers (ALU). Studies carried out on animal models have shown that intestinal dysbiosis may be related to the development of autoimmune diseases, even if the mechanisms involved are not yet well known. The aim of this paper is to verify the hypothesis that in inflammator…

How do skeletal morbidity rate and special toxicities affect 12-week versus 4-week schedule zoledronic acid efficacy? A systematic review and a meta-…

2019

Abstract Background Zoledronic Acid is a bisphosphonate used in a 4-week schedule for the treatment of bone metastases. Some randomized trials supported its role also when administered every 12 weeks. Methods we performed a systematic review and a meta-analysis in order to evaluate the two different schedules in terms of skeletal morbidity rate (SMR), skeletal related events (SRE) and adverse events (AEs). Results our results showed a clinical difference favouring the 12-week schedule in terms of AEs (RR 1.17, 95% CI 1.06–1.29). No signifcant differences were found for SMR (RR 0.97, 95% CI 0.84–1.13) and SRE (RR 1.02, 95% CI 0.89–1.16). Conclusions Our findings support in clinical practice …

Primary angiosarcoma of the alveolar mucosa in a haemodialysis patient: case report and discussion

1994

A case of a haemodialysis patient with a primitive angiosarcoma of the alveolar mucosa is reported. The vascular origin of the tumor was confirmed by the immunohistochemical data which showed strong positivity for Factor VIII-related antigen and for vimentin, whereas stains for desmin and cytokeratins were negative.

In vitro activities of antimicrobial agents against Candida species

1999

Objective. Antimicrobial mouthrinses may represent a valid alternative to topical antifungal agents. However, the action of antimicrobials could be affected by the different ingredients incorporated into mouthrinse products. The purpose of the present study was to investigate the in vitro antifungal and fungicidal activities of antimicrobials alone. Study Design. A broth macrodilution method was used to determine the minimum inhibitory concentration of 4 antimicrobial agents against Candida species. Minimum fungicidal concentration was also determined. Results. All antimicrobials showed antifungal activity against all tested organisms, but cetylpyridinium chloride received significantly low…

Community water fluoridation and caries prevention: a critical review.

2006

The aim of this paper was to critically review the current role of community water fluoridation in preventing dental caries. Original articles and reviews published in English language from January 2001 to June 2006 were selected through MEDLINE database. Other sources were taken from the references of the selected papers. For the past 50 years community water fluoridation has been considered the milestone of caries prevention and as one of the major public health measures of the 20th century. However, it is now accepted that the primary cariostatic action of fluoride occurs after tooth eruption. Moreover, the caries reduction directly attributable to water fluoridation have declined in the…

Assessment of tobacco dependence curricula in Italian dental hygiene schools

2013

The aim of this study was to assess the level of tobacco dependence education offered by Italian dental hygiene programs. A fifty-question survey was mailed to the thirty-one active public and private dental hygiene programs in Italy during the 2008-09 academic year. The survey assessed faculty confidence in teaching tobacco treatment, which courses contained tobacco dependence content, the number of minutes spent on specific content areas, and the level of clinical competence that dental hygiene graduates should be able to demonstrate. Surveys were returned by sixteen programs for a response rate of 52 percent. Respondents indicated tobacco dependence education was included in clinic or cl…

Topical Fluoride for Preventing Dental Caries in Children and Adolescents

2012

The use of topically applied fluoride has been widely researched as a means to reduce the risk of dental caries in conjunction with other treatment modalities (mechanical oral hygiene, dietary control, antimicrobial intervention, pit and fissure sealants). There is overwhelming evidence that reports not only the significance and importance of the use of fluoride as a caries-preventive agent, but also how safe fluoride application is when used appropriately, particularly in higher risk individuals and populations. This paper reviews the caries-protective benefits of topical fluoride application in children and adolescents, with an emphasis on the clinical efficacy and safety of the vehicles …

Paediatric Sleep Questionnaire for Obstructive Sleep Apnoea Syndrome Screening: Is Sleep Quality Worthy of Note?

2021

Obstructive sleep apnoea syndrome (OSAS) is the most severe condition on the spectrum of sleep-related breathing disorders (SRBDs). The Paediatric Sleep Questionnaire (PSQ) is one of the most used and validated screening tools, but it lacks the comprehensive assessment of some determinants of OSAS, specifically anamnestic assessment and sleep quality. This study aims to assess the accuracy of some specific items added to the original PSQ, particularly related to the patient’s anamnestic history and to the quality of sleep, for the screening of OSAS in a paediatric population living in Sicily (Italy). Fifteen specific items, divided into “anamnestic” and “related to sleep quality” were added…

Occurrence of invading bacteria in radicular dentin of periodontally diseased teeth: Microbiological findings

1997

Bacterial invasion in roots of periodontally diseased teeth, which has been recently documented using cultural and microscopic techniques, may be important in the pathogenesis of periodontal disease. The purpose of this investigation was to determine the occurrence and the species of invading bacteria in radicular dentin of periodontally diseased teeth. Samples were taken from the middle layer of radicular dentin of 26 periodontally diseased teeth. 14 healthy teeth were used as controls. Dentin samples were cultured anaerobically. The chosen methodology allowed the determination of the numbers of bacteria present in both deeper and outer part of dentinal tubules, and the bacterial concentra…

I denti decidui. Anatomia e fisiologia

2006

Advances in paediatric restorative dentistry

2009

Dental caries has been a highly prevalent and costly disease in the world, representing the most common infectious disease in the paediatric population. Caries lesions are also increasingly isolated in specific teeth and tooth morphology types, and there is growing controversy about the most appropriate restorative material for these lesions in deciduous teeth. In fact, restorative materials continuously improved in durability, strength, aesthetics, and anti-cariogenic properties. Moreover, the increasing demand for aesthetic restorative treatment has totally transformed the practice of paediatric dentistry in the last decade. Traditionally, the use of amalgam was a standard procedure in th…

Salute orale in età pediatrica: indagine epidemiologica in un campione di soggetti della città di Palermo.

2007

Il ruolo dell'igienista dentale nel counselling anti-tabacco

2006

Salute orale e diabete mellito di tipo I (IDDM): indagine su un campione di soggetti in età pediatrica

2004

Tecniche diagnostiche innovative per la diagnosi precoce della carie dentale

2009

Sindrome di Ehlers-Danlos: manifestazioni orali in due gemelle omozigoti.

2005

Counselling anti-fumo e team odontoiatrico.

2006

The aim of this paper was to present specific strategies to guide dental professionals providing smoking cessation interventions. Original papers, reviews and current guidelines on this subject, published in English from 2001 to the first semester of 2005, were located in the MEDLINE/Pubmed database. Additional publications were obtained by searching the reference lists of retrieved studies. The "Five A's" strategic approach represents a brief and effective protocol for smoking cessation that members of dental team can use with all patients in their office practice. Intensive interventions, more effective than brief ones, can be further adopted with any smokers willing to make a quit attemp…

A RAPID AND SENSITIVE METHOD TO DETECT CLASS II ALLELES IN THE SALIVA ASSOCIATED WITH CELIAC DISEASE

2013

Valutazione della forza di un sistema adesivo su dentina di denti decidui

2008

Traumatic dental injuries: preventive and public health approaches

2009

Dental trauma can involve injuries to hard tissues and pulp, to periodontal tissues, to bone tissue, and to gingiva and oral mucosa. The aetiology of dental injuries is multi-factorial as they are caused by a complex array of individual clinical factors and social/environmental determinants. Traumatic dental injuries are mainly sustained during sports, through accidents and as a direct result of violence. The prevalence of traumatic dental injuries is not high but there is evidence that the incidence in children’s teeth is increasing. Primary prevention of traumatic dental injuries addresses the control of preventable risk factors through the early treatment of large overjet, the provision …

Accuratezza del DIAGNOdent Pen nell’individuazione di lesioni cariose occlusali in denti decidui e permanenti

2009

Salute orale in età pediatrica: indagine epidemiologica in un campione di popolazione della città di Palermo

2007

The effects of two essential oil mouthrinses on supragingival plaque regrowth: a comparative in vivo study

2010

Malattia celiaca e ulcere orali:prevalenza ed associazione con la dieta gluten-free

2007

Terapia farmacologica in odontoiatria pediatrica

2012

Patologie parodontali in età pediatrica

2005

Le patologie parodontali, sebbene più frequenti nel soggetto adulto, sono riscontrabili anche in età pediatrica con valori di prevalenza più elevati negli adolescenti (12-17 anni). Tali patologie sono caratterizzate da reperti clinici spesso aspecifici. Esse riconoscono sovente fattori eziologici locali, ma possono pure essere influenzate, nel loro decorso clinico e nella gravità, dalle condizioni di salute generale del piccolo paziente. In alcuni casi, inoltre, l’insorgenza di lesioni a carico dei tessuti parodontali può essere la prima manifestazione di patologie extra orali.

Socio-behavioural determinants of dental caries in schoolchildren in the city of Palermo, Southern Italy

2008

Manifestazioni orali della sindrome di Smith-Lemli-Opitz: un case report.

2005

Studio retrospettivo sulla candidosi orale

2004

Caries Severity, Decayed First Permanent Molars and Associated Factors in 6-7 Years Old Schoolchildren Living in Palermo (Southern Italy).

2023

To date, there are very few epidemiologic studies on caries disease in 6–7 year old children living in Sicily (Southern Italy). The first permanent molar (FPM) is the most commonly affected tooth in this target population, and a one-unit increase in the number of decayed FPMs is predictive of caries in other teeth and in adulthood. The primary aim of this research is to estimate the prevalence of caries in 6–7 year old schoolchildren living in Palermo and, as a secondary aim, to estimate the prevalence of affected FPMs. It was designed as a cluster cross-sectional survey on 995 children from 16 schools, selected based on their geographical location, in one of the eight city districts. Carie…

Il mantenimento della salute orale nel paziente in trattamento ortodontico

2008

I trattamenti ortodontici vengono eseguiti con dispositivi rimovibili o fissi che, modificando l’ecosistema del cavo orale, aumentano il rischio d’insorgenza e progressione di lesioni cariose e di malattia parodontale. Pertanto, occorre attuare un protocollo individualizzato di prevenzione che preveda un adeguato addestramento all’igiene orale domiciliare, con rinforzi motivazionali nelle varie fasi del trattamento ortodontico, e l’attuazione di programmi di fluoroprofilassi topica professionale e domiciliare. Fixed or removable appliances impede the maintenance of good oral hygiene resulting in dental plaque accumulation. Plaque retention surrounding orthodontic appliances can increase the…

The mesiodistal crown diameters in Sicilian schoolchildren

2010

Lesioni odontostomatologiche in corso di malattia celiaca

2006