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RESEARCH PRODUCT
Probiotics Can Cure Oral Aphthous-Like Ulcers in Inflammatory Bowel Disease Patients: A Review of the Literature and a Working Hypothesis
Dario SagutoFederica CanepaGiuseppina CampisiGiuseppe BonaventuraFrancesca RappaGiovanna GiulianaAlberto FucarinoAngelo LeoneFederica ScaliaMargherita MazzolaFrancesco CappelloFabio BucchieriFrancesco CariniGiovanni Tomasellosubject
0301 basic medicineInflammationReviewWorking hypothesisInflammatory bowel diseaseinflammatory bowel diseasesCatalysisInorganic Chemistrylcsh:Chemistry03 medical and health sciences0302 clinical medicineinflammatory bowel diseasemedicinemicrobiotaaphthous-like ulcersAnimalsHumansPhysical and Theoretical ChemistryOral mucosaMolecular BiologyStomatitislcsh:QH301-705.5SpectroscopyNatural coursebusiness.industrydysbiosiOrganic ChemistryInflammatory Bowel DiseasesGeneral Medicinedysbiosismedicine.diseasemuco-microbiotic layerdigestive system diseasesComputer Science ApplicationsGastrointestinal MicrobiomeDisease Models Animalstomatognathic diseases030104 developmental biologymedicine.anatomical_structureprobioticslcsh:Biology (General)lcsh:QD1-999030220 oncology & carcinogenesisImmunologyStomatitis Aphthousmedicine.symptombusinessDysbiosisaphthous-like ulcerdescription
Dysbiosis has been associated with the onset of several chronic autoimmune or inflammatory pathologies (e.g., inflammatory bowel diseases—IBD), because of its primary role in the establishment of a chronic inflammatory process leading to tissue damage. Inflammatory bowel diseases can even involve areas far away from the gut, such as the extraintestinal manifestations involving the oral cavity with the onset of aphthous-like ulcers (ALU). Studies carried out on animal models have shown that intestinal dysbiosis may be related to the development of autoimmune diseases, even if the mechanisms involved are not yet well known. The aim of this paper is to verify the hypothesis that in inflammatory bowel diseases patients, aphthous-like ulcers are the result of the concomitance of intestinal dysbiosis and other events, e.g., the microtraumas, occurring in the oral mucosa, and that ex adiuvantibus therapy with probiotics can be employed to modify the natural course of the aphthous-like ulcers.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-10-01 | International Journal of Molecular Sciences |