0000000000952974

AUTHOR

Yu-tzu Wu

showing 3 related works from this author

Inflammation and frailty in the elderly: A systematic review and meta-analysis

2016

The pathogenesis of frailty and the role of inflammation is poorly understood. We examined the evidence considering the relationship between inflammation and frailty through a systematic review and meta-analysis. A systematic literature search of papers providing data on inflammatory biomarkers and frailty was carried out in major electronic databases from inception until May 2016. From 1856 initial hits, 35 studies (32 cross-sectional studies n = 3232 frail, n = 11,483 pre-frail and n = 8522 robust, and 563 pre-frail + robust; 3 longitudinal studies n = 3402 participants without frailty at baseline) were meta-analyzed. Cross-sectional studies reported that compared to 6757 robust participa…

GerontologyMalemedicine.medical_specialtyAgingNeurologyFrail ElderlyInflammationPre-frailtyBiochemistry03 medical and health sciencesFibrinogen levels0302 clinical medicineInternal medicineWhite blood cellmedicine80 and overHumans030212 general & internal medicineMolecular BiologyAgedAged 80 and overInflammationbiologyInflammation Pre-frailty Frailty Aging C-Reactive proteFrailtybusiness.industryInterleukin-6C-reactive proteinC-Reactive proteinInflammatory biomarkersAgeingmedicine.anatomical_structureAging; C-Reactive protein; Frailty; Inflammation; Interleukin-6; Pre-frailty; Aged; Aged 80 and over; Biomarkers; Cytokines; Female; Humans; Inflammation; Male; Frail ElderlyNeurologyMeta-analysisbiology.proteinCytokinesFemalemedicine.symptombusiness030217 neurology & neurosurgeryBiomarkersSystematic searchBiotechnologyAging; C-Reactive protein; Frailty; Inflammation; Interleukin-6; Pre-frailty
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Latent structure of the Centre for Epidemiologic Studies Depression Scale (CES-D) in older adult populations: a systematic review

2019

Objective: The Center for Epidemiologic Studies Depression Scale (CES-D) is a 20-item, self-report metric intended to measure depression. Despite being one of the most popular depression scales, the psychometric properties, specifically the underlying factor structure of the scale, have come under scrutiny. The latent structure of a scale is a key indicator of its construct validity, i.e. the degree to which the intended variable is captured. To date, a comprehensive review of the latent structure of the CES-D in older adult populations (≥65 years old) has not been conducted. We aimed to examine the latent structure of the CES-D in samples of older adults to assess its ability to capture de…

PsychometricsDepression scaleFactor structurebehavioral disciplines and activitiesfactor structure03 medical and health sciences0302 clinical medicineolder adults.HumansLatent structureCenter for Epidemiologic Studies Depression ScaleDepression (differential diagnoses)AgedPsychiatric Status Rating Scales030214 geriatricsDepressionReproducibility of ResultsCenter for Epidemiologic Studies Depression ScaleUnited StatesPsychiatry and Mental healthEpidemiologic StudiesMetric (unit)Self ReportGeriatrics and GerontologyPshychiatric Mental HealthPsychologyFactor Analysis StatisticalGerontology030217 neurology & neurosurgeryClinical psychology
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Depression and Incidence of Frailty in Older People From Six Latin American Countries

2019

ObjectiveFrailty and depression are highly comorbid conditions, but the casual direction is unclear and has not been explored in low- and middle-income countries. The aim of this study was to investigate the potential impact of depression on incident frailty in older people living in Latin America.MethodsThis study was based on a population-based cohort of 12,844 people aged 65 or older from six Latin American countries (Cuba, Dominican Republic, Mexico, Venezuela, Puerto Rico, and Peru), part of the 10/66 cohort study. Two types of frailty measures were used: a modified Fried frailty phenotype and a multidimensional frailty criterion, which included measures from cognition, sensory, nutrit…

MaleAged 80 and overInternationalityFrailtyDepressionFrail ElderlyIncidencefrailtyArticleLatin AmericaSocioeconomic Factorsolder ageHumansDementiaFemaleepidemiologylow- and middle-income countriesDeveloping CountriesGeriatric AssessmentAgedThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
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