A no-carrier-added 72Se/72As isotope generator

2001

Siinznrary A no-carrier-added 72Se/72As generator has been developed for the isolation of 72As, relevant for eventual application in the syntheses of 72As-labelled radiophamaceuticals. Avoiding the addition of Se carrier and using a thennochromatographic destillation process, no-carrier-added 72As is nearly quantitatively released within 10 min. 72Se remains almost quantitatively (> 99.7%) in solution when a temperature of the separation process of 100°C is applied. Introdiiction Arsenic-72 is a positron emitting isotope with properties which are promising for eventual application in 72As-labelled radiopharmaceuticals. It has n positron emission rate of 88% and positron energies of EP+,,,,~…

Excitation Functions of 14N(d,t)13N and 14N(d,αn)11C Reactions from Threshold to 12.3 MeV : Radionuclidic Purity of 150 Produced via the 14N(d,n)15O …

1998

A new method for radiochemical separation of arsenic from irradiated germanium oxide.

2005

Abstract Radioarsenic labelled radiopharmaceuticals could be a valuable asset to Positron Emission Tomography (PET). In particular, the long half-lives of 72 As ( T 1/2 =26 h) and 74 As ( T 1/2 =17.8 d) allow to investigate slow physiological or metabolical processes, like the enrichment and distribution of antibodies in tumor tissue. This work describes the direct production of no-carrier-added (nca) arsenic isotopes *As, with *=71, 72, 73, 74 or 77, the reaction to [*As]AsI 3 and its radiochemical separation from the irradiated solid germanium oxide via polystyrene-based solid-phase extraction. The germanium oxide target, irradiated at a cyclotron or a nuclear reactor, is dissolved in con…