6533b859fe1ef96bd12b8137
RESEARCH PRODUCT
A new method for radiochemical separation of arsenic from irradiated germanium oxide.
Nikolai V SlavinePadmakar V KulkarniAlex HermannePhilip E. ThorpeRalph P. MasonMarc JenneweinFrank RöschE. TsyganovS. SeliounineS. M. QaimP.a. AntichMarkus Jahnsubject
RadioisotopesRadiationGermaniumExtraction (chemistry)RadiochemistryHalidechemistry.chemical_elementIodineArsenicchemistry.chemical_compoundHydrofluoric acidchemistryYield (chemistry)Positron-Emission TomographySolid phase extractionRadiopharmaceuticalsArsenicGermanium oxideNuclear chemistryHalf-Lifedescription
Abstract Radioarsenic labelled radiopharmaceuticals could be a valuable asset to Positron Emission Tomography (PET). In particular, the long half-lives of 72 As ( T 1/2 =26 h) and 74 As ( T 1/2 =17.8 d) allow to investigate slow physiological or metabolical processes, like the enrichment and distribution of antibodies in tumor tissue. This work describes the direct production of no-carrier-added (nca) arsenic isotopes *As, with *=71, 72, 73, 74 or 77, the reaction to [*As]AsI 3 and its radiochemical separation from the irradiated solid germanium oxide via polystyrene-based solid-phase extraction. The germanium oxide target, irradiated at a cyclotron or a nuclear reactor, is dissolved in concentrated HF and Ge is separated almost quantitatively (99.97%) as [GeF 6 ] 2− . [*As]AsI 3 is formed by addition of potassium iodide. The radiochemical separation yield for arsenic is >90%. [*As]AsI 3 is a versatile radioarsenic labelling synthon.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-03-05 | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine |