0000000000964596
AUTHOR
H. Wiendl
Therapieziele von Basis- und Eskalationstherapien zur Behandlung der schubförmig-remittierenden Multiplen Sklerose
Vor dem Hintergrund der Verfugbarkeit neuer, hochwirksamer MS-Therapeutika und der besonderen Bedeutung des fruhen Krankheitsverlaufs fur die Prognose der MS kommt der Definition von Therapiezielen starkere Bedeutung zu. Insbesondere die Erstellung von Kriterien fur eine rechtzeitige Eskalationstherapie bei MS-Patienten ist eine relevante Frage der alltaglichen Versorgung. Leider fehlen fur diese Fragestellung Studienergebnisse mit Klasse-I-Evidenz. Im Rahmen eines industrieunterstutzten Expertenmeetings wurden Therapieziele von immunmodulatorischen Basis- und Eskalationstherapien fur Patienten mit schubformig-remittierender MS und Kriterien fur die rechtzeitige Umstellung auf Eskalationsth…
Multiple Sclerosis Therapy Consensus Group (MSTCG): position statement on disease-modifying therapies for multiple sclerosis (white paper)
Multiple sclerosis is a complex, autoimmune-mediated disease of the central nervous system characterized by inflammatory demyelination and axonal/neuronal damage. The approval of various disease-modifying therapies and our increased understanding of disease mechanisms and evolution in recent years have significantly changed the prognosis and course of the disease. This update of the Multiple Sclerosis Therapy Consensus Group treatment recommendation focuses on the most important recommendations for disease-modifying therapies of multiple sclerosis in 2021. Our recommendations are based on current scientific evidence and apply to those medications approved in wide parts of Europe, particular…
DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning
Genome-wide association studies (GWAS) identify genetic variants associated with traits or diseases. GWAS never directly link variants to regulatory mechanisms. Instead, the functional annotation of variants is typically inferred by post hoc analyses. A specific class of deep learning-based methods allows for the prediction of regulatory effects per variant on several cell type-specific chromatin features. We here describe “DeepWAS”, a new approach that integrates these regulatory effect predictions of single variants into a multivariate GWAS setting. Thereby, single variants associated with a trait or disease are directly coupled to their impact on a chromatin feature in a cell type. Up to…
Supplementary Material for: Targeting Voltage-Dependent Calcium Channels with Pregabalin Exerts a Direct Neuroprotective Effect in an Animal Model of Multiple Sclerosis
Background/Aims: Multiple sclerosis (MS) is a prototypical autoimmune central nervous system (CNS) disease. Particularly progressive forms of MS (PMS) show significant neuroaxonal damage as consequence of demyelination and neuronal hyperexcitation. Immuno-modulatory treatment strategies are beneficial in relapsing MS (RMS), but mostly fail in PMS. Pregabalin (Lyrica®) is prescribed to MS patients to treat neuropathic pain. Mechanistically, it targets voltage-dependent Ca2+ channels and reduces harmful neuronal hyperexcitation in mouse epilepsy models. Studies suggest that GABA analogues like pregabalin exert neuroprotective effects in animal models of ischemia and trauma. Methods: We tested…