0000000000969707
AUTHOR
Noël Peretti
Multi-omics profiling reveals that eating difficulties developed consecutively to artificial nutrition in the neonatal period are associated to specific saliva composition.
Prolonged enteral or parenteral nutrition in neonatal periods sometimes results in eating difficulties persisting for years, with reduced food intake through the oral route and thereby reduced stimulation of the oral cavity. Aiming at describing the consequences on oral physiology, saliva of 21 children with eating difficulties (ED) was compared to that of 23 healthy controls, using various omics and targeted methods. Overall, despite heterogeneity within the groups (age, medication etc.), the three spectral methods (MALDI-TOF, SELDI-TOF, (1)H NMR) allowed discriminating ED and controls, confirming that oral stimulation by food intake plays a role in shaping the composition of saliva. Saliv…
Early artificial nutrition: consequences on feeding disorders in children
Background and objectives: several pathologies (metabolic, neurologic and prematurity) may involve. the use of artificial nutrition (AN) in the first months of life. The absence of oral feeding during this. essential period for the formation of eating behavior may be associated to long-term deleterious. consequences, especially when it is associated to an invasive treatment (i.e. naso-gastric tubing). The. objective here was 1) to develop a questionnaire aimed at characterizing feeding disorders, food. preferences and food habits in children with (FD) or without feeding disorders (CT) ; and 2) to evaluate. the consequences of timing of early AN on eating behavior. Methods: FD children were …
Associations between food consumption patterns and saliva composition: Specificities of eating difficulties children
Identifying objective markers of dietwould be beneficial to research fields such as nutritional epidemiology. As a preliminary study on the validity of using saliva for this purpose, and in order to explore the relationship between saliva and diet, we focused on clearly contrasted groups of children: children with eating difficulties (ED) receiving at least 50% of their energy intake through artificial nutrition vs healthy controls (C). Saliva of ED and C children was analyzed by various methods (targeted biochemical analyses, 2-D electrophoresis coupled to MS, 1H NMR) and their diet was characterized using food frequency questionnaires, considering 148 food items grouped into 13 categories…
Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)
Background The European Atherosclerosis Society Familial Hypercholesterolaemia Studies Collaboration (FHSC) global registry provides a platform for the global surveillance of familial hypercholesterolaemia through harmonisation and pooling of multinational data. In this study, we aimed to characterise the adult population with heterozygous familial hypercholesterolaemia and described how it is detected and managed globally. Methods Using FHSC global registry data, we did a cross-sectional assessment of adults (aged 18 years or older) with a clinical or genetic diagnosis of probable or definite heterozygous familial hypercholesterolaemia at the time they were entered into the registries. Dat…
Caractériser les troubles du comportement alimentaire de l’enfant atteint de dysoralité
Introduction et objectif : Différentes pathologies (métaboliques, neurologiques, prématurité) peuvent nécessiter le recours à une alimentation artificielle dans les premiers mois de vie. L’absence d’alimentation par voie orale lors de cette période essentielle de la formation du comportement alimentaire, surtout lorsqu’elle est associée à un traitement invasif (i.e. sonde naso-gastrique), peut s’accompagner de conséquences à long terme sur le comportement alimentaire. L’objectif est de développer un questionnaire évaluant le comportement, les préférences et les habitudes alimentaires d’enfants atteints de dysoralité (TO), en comparaison avec des enfants sains (STO). Méthode : L’inclusion de…
Children with eating disorders secondarily to artificial nutrition in the neonatal period have specific food preferences and saliva composition
- Objectives and studyIn the neonatal period, some severe digestive diseases require the cessation of oral feeding and the use of enteral or parenteral nutrition for prolonged periods. In some cases, this by-pass of the oral cavity during the early stages of feeding results in the development of so-called oral disorders (OD). Oral disorders may persist for years after healing of the causal disease, and are expressed for example by an exacerbated gag reflex, difficulties in chewing and swallowing and high food selectivity.The aim of this study were to describe the consequences on oral physiology of oral by-pass and enteral nutrition in a population of 21 children who suffered oral disorder (…
Etude du comportement alimentaire des enfants ayant un syndrome de Silver-Russell
National audience; Introduction et but de l’étude. – Le syndrome de Silver-Russell (SSR) est une maladie épigénétique rare caractérisée par un retard de croissance intra-utérin avec périmètre crânien relativement préservé, une petite taille post-natale associée à une dysmorphie et une asymétrie corporelle inconstante. Des difficultés alimentaires majeures sont souvent décrites pouvant nécessiter le recours à une nutrition entérale prolongée. À ce jour, aucune étude n’a décrit précisément les troubles du comportement alimentaire de ces enfants. Le but de notre travail était donc de caractériser les différentes composantes du comportement alimentaire d’enfants ayant un SSR. Matériel et méthod…
Oral sphere: salivary markers and food. A prospective study on children expressing oral disorders
National audience