The polyelectrolytes and the Hofmeister series of anions: polyGC chemical denaturation in aqueous solution

Complexes of organometallic compounds

Abstract Several new complexes formed by PhTlCl 2 with tridentate ligands (with ONO and SNO donor atoms) and a tetradentate ligand (with ONNO donor atoms), have been prepared. The complexes show 1/1 organothallium(lll)/Ligand ( = L 2− ) stoichiometry. Their nature and configuration are investigated in the solid state by vibrational spectroscopy, and in solution by electronic spectroscopy. The existence of chelation by the dianionic ligands on Tl III is inferred, and suggestions are made concerning the Tl III coordination number and the stereochemistry of the complexes.

Efficacy and safety of Everolimus and Exemestane in hormone-receptor positive (HR+) human-epidermal-growth-factor negative (HER2−) advanced breast cancer patients: New insights beyond clinical trials. The EVA study

Abstract Background The BOLERO-2 trial reported efficacy and safety of Everolimus (EVE) and Exemestane (EXE) combination in HR+ advanced breast cancer (ABC) patients. The BALLET trial further evaluated the safety of EVE-EXE in HR+ ABC patients, without reporting efficacy data. Aim of the EVA real-life study was to collect data of efficacy and safety of EVE-EXE combination in the clinical setting, as well as exploring efficacy according to EVE Dose-Intensity (DI) and to previous treatment with Fulvestrant. Patients and methods This study aimed to describe the outcome of ABC pts treated with EVE-EXE combination in terms of median duration of EVE treatment and ORR in a real-life setting. Resul…

Cationic microemulsion hosting polynucleotides: Effect of NaCl on host and guest

The structural features of the quaternary water-in-oil microemulsion CTAB/n-hexane/n-pentanol/water in the presence of fairly high concentrations of NaCl and of relatively high molecular weight polynucleotides have been determined. Even in these severe conditions, the hosting system can still be depicted as formed by water droplets stabilised by a surfactant/cosurfactant layer. Moreover, the time stability of the host/guest system has been evaluated and the phase behaviour of the hosting system in the presence of increasing concentrations of NaCl determined.

Everolimus (EVE) and exemestane (EXE) in patients with advanced breast cancer aged ≥ 65 years: New lessons for clinical practice from the EVA study

BACKGROUND: The present analysis focuses on real-world data of Everolimus- Exemestane in advanced HR+ve, HER2-ve elderly breast cancer patients (aged 65 years) included in the EVA study, with unique findings in those aged 70 years. METHODS: Data are collected from clinical records and analysed according to age cut-off (< 65 years; 65 - 69 years and [greater than or equal to] 70 years). Relationship of analyzed variables with response were tested by mean of a Mantel- Haenszel chi square test. Time to event analysis was described by Kaplan Meier approach and association with baseline characteristics was analysed by stratified log-rank test and proportional hazard model. RESULTS: From July …