0000000000977417
AUTHOR
V. López
A new PCR-based method for monitoring inoculated wine fermentations.
A new PCR-based method has been developed to monitor inoculated wine fermentations. The method is based on the variation in the number and position of introns in the mitochondrial gene COX1. Oligonucleotide primers homologous to the regions flanking the Saccharomyces cerevisiae COX1 introns have been designed and tested for S. cerevisiae wine yeast strain differentiation. Four primers were selected for their subsequent use in a multiplex PCR reaction and have proved to be very effective in uncovering polymorphism in natural and commercial yeast strains. An important point is that the speed and simplicity of the technique, which does not require the isolation of DNA, allows early detection o…
Actualización en el síndrome Birt-Hogg-Dubé
Resumen El sindrome de Birt-Hogg-Dube (SBHD) es una rara genodermatosis de herencia autosomica dominante caracterizada esencialmente por la presencia de fibrofoliculomas y/o tricodiscomas, quistes pulmonares, neumotorax espontaneos y canceres renales, siendo los tipos histologicos mas frecuentes las formas hibridas de oncocitoma y carcinoma cromofobo o formas puras de carcinoma cromofobo, oncocitico, de celulas claras o papilar. El gen implicado en este sindrome, FLCN, codifica la foliculina, que se expresa preferentemente a nivel cutaneo, renal y pulmonar. Este sindrome puede presentarse con una gran variabilidad clinica, y las lesiones cutaneas que son el signo de alarma para los dermatol…
Descriptive Dermoscopic Study of Depigmentation in Melanocytic Nevi Without a Visible Halo
Background and objectives: There are few cases described in the literature in which depigmentation of melanocytic nevi occurs without the appearance of halos. The aim of this study was to analyze the correlation between clinical and dermoscopic findings and to assess the usefulness of dermoscopy to identify possible markers of complete regression in melanocytic lesions. Materials and methods: A prospective, observational, descriptive study of 77 melanocytic lesions in 52 patients was undertaken over a 5-year period. Melanocytic lesions from patients who underwent periodic follow-up in the digital dermoscopy unit were analyzed if they had exhibited partial or total, permanent depigmentation …
Estudio descriptivo dermatoscópico de los nevos melanocíticos con despigmentación sin halo clínico
Resumen Introduccion la despigmentacion de nevos melanociticos sin halo perilesional se ha descrito de forma excepcional en la literatura. Material y metodos estudio observacional, descriptivo y prospectivo de 77 lesiones melanociticas correspondientes a 52 pacientes, llevado a cabo durante un periodo de 5 anos. Se han analizado las lesiones melanociticas de pacientes revisados periodicamente en la unidad de dermatoscopia digital que habian sufrido una despigmentacion permanente, ya fuera total o parcial, pero sin presentar clinicamente un halo blanquecino alrededor de los mismos. El objetivo fue estudiar la correlacion entre los hallazgos clinicos y dermatoscopicos a estudio, y establecer …
Birt–Hogg–Dubé Syndrome: An Update
Birt-Hogg-Dube syndrome is a rare autosomal dominant genodermatosis that is characterized by the presence of fibrofolliculomas and/or trichodiscomas, pulmonary cysts, spontaneous pneumothorax, and renal tumors. The most common histological types found in renal tumors from patients with the syndrome are oncocytoma-chromophobe carcinoma hybrids and pure forms of chromophobe carcinoma, oncocytic carcinoma, and clear cell or papillary cell carcinoma. The syndrome is linked to mutations in the FLCN gene, which encodes folliculin and is preferentially expressed in the skin, kidney, and lung. The syndrome can exhibit a high degree of clinical variability, and the skin lesions that are a warning si…