0000000000986036

AUTHOR

Mónica De La Fuente

showing 3 related works from this author

Human exceptional longevity: transcriptome from centenarians is distinct from septuagenarians and reveals a role of Bcl-xL in successful aging.

2016

24 páginas, 7 figuras. Borras C, et al. Human exceptional longevity: transcriptome from centenarians is distinct from septuagenarians and reveals a role of Bcl-xL in successful aging. Aging (Albany NY). 2016 Oct 28;8(12):3185-3208. doi: 10.18632/aging.101078.

0301 basic medicineAgingFAS ligandmedia_common.quotation_subjectBiologíaLongevitybcl-X ProteinBcl-xLPeripheral blood mononuclear cellFas ligandTranscriptome03 medical and health sciences0302 clinical medicineAnimalsHumansBcl-2RNA MessengerCaenorhabditis elegansmedia_commonAgedGeneticsAged 80 and overSuccessful agingbiologyLongevityapoptosisCell BiologyGenéticaUp-RegulationRNA; apoptosis030104 developmental biologyhealthy agingGene Expression RegulationApoptosis030220 oncology & carcinogenesisbiology.proteinRNATranscriptomeLeukocyte chemotaxisResearch Paper
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Adverse Effects of Diabetes Mellitus on the Skeleton of Aging Mice

2016

In the present study, the possibility that a diabetic (DM) status might worsen age-related bone deterioration was explored in mice. Male CD-1 mice aged 2 (young control group) or 16 months, nondiabetic or made diabetic by streptozotocin injections, were used. DM induced a decrease in bone volume, trabecular number, and eroded surface, and in mineral apposition and bone formation rates, but an increased trabecular separation, in L1-L3 vertebrae of aged mice. Three-point bending and reference point indentation tests showed slight changes pointing to increased frailty and brittleness in the mouse tibia of diabetic old mice. DM was related to a decreased expression of both vascular endothelial …

Male0301 basic medicineSenescenceAgingmedicine.medical_specialtyBone densityOsteoporosisDiabetes Mellitus ExperimentalBone remodelingMice03 medical and health scienceschemistry.chemical_compoundSDG 3 - Good Health and Well-beingBone DensityOsteogenesisDiabetes mellitusInternal medicineAnimalsMedicineLumbar Vertebraebusiness.industryStreptozotocinmedicine.diseaseVascular endothelial growth factor030104 developmental biologyEndocrinologymedicine.anatomical_structurechemistryOsteoporosisBone RemodelingBone marrowGeriatrics and GerontologyTomography X-Ray Computedbusinessmedicine.drugThe Journals of Gerontology Series A: Biological Sciences and Medical Sciences
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Frailty Quantified by the "Valencia Score" as a Potential Predictor of Lifespan in Mice.

2017

The development of frailty scores suitable for mice and which resemble those used in the clinical scenario is of great importance to understand human frailty. The aim of the study was to determine an individual frailty score for each mouse at different ages and analyze the association between the frailty score and its lifespan. For this purpose, the "Valencia Score" for frailty was used. Thus, a longitudinal study in mice was performed analyzing weight loss, running time and speed, grip strength and motor coordination at the late-adult, mature and old ages (40, 56 and 80 weeks old, respectively). These parameters are equivalent to unintentional weight loss, poor endurance, slowness, weaknes…

0301 basic medicineGerontologyWeaknessLongitudinal studyAgingFrail ElderlyLongevityHealthy Aging03 medical and health sciencesGrip strengthMice0302 clinical medicineWeight lossWeight LossmedicineAnimalsHumansLongitudinal StudiesMaze LearningClinical scenarioGeriatric AssessmentAgedMice Inbred ICRFrailtyHand Strengthbusiness.industryLow activityAging PrematureRunning timeMotor coordination030104 developmental biologyPhenotypeModels AnimalPhysical EnduranceFemaleGeriatrics and Gerontologymedicine.symptombusiness030217 neurology & neurosurgeryThe journals of gerontology. Series A, Biological sciences and medical sciences
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