0000000000999968

AUTHOR

Anna Maria Marotta

showing 7 related works from this author

Liver Steatosis and Fibrosis in OSA patients After Long-term CPAP Treatment: A Preliminary Ultrasound Study.

2015

In cases of morbid obesity, obstructive sleep apnea (OSA) was associated with biopsy-proven liver damage. The role of non-invasive techniques to monitor liver changes during OSA treatment with continuous positive airway pressure (CPAP) is unknown. We used non-invasive ultrasound techniques to assess liver steatosis and fibrosis in severe OSA patients at diagnosis and during long-term CPAP treatment. Fifteen consecutive patients with severe OSA (apnea hypopnea index 52.5 ± 19.1/h) were studied by liver ultrasound and elastography (Fibroscan) at 6-mo (n = 3) or 1-y (n = 12) follow-up. Mean age was 49.3 ± 11.9 y, body mass index (BMI) was 35.4 ± 6.4 kg/m(2). Adherence to CPAP was ≥5 h/night. A…

Liver CirrhosisMalemedicine.medical_specialtyAcoustics and Ultrasonicsmedicine.medical_treatmentBiophysicsSettore MED/10 - Malattie Dell'Apparato RespiratorioGastroenterologyBody Mass IndexTime03 medical and health sciences0302 clinical medicineFibrosisInternal medicinemedicineHumansRadiology Nuclear Medicine and imagingObesityContinuous positive airway pressureNon-invasive assessmentUltrasonographySleep Apnea ObstructiveRadiological and Ultrasound Technologymedicine.diagnostic_testContinuous Positive Airway Pressurebusiness.industryFatty liverLiver fibrosiMiddle Agedmedicine.diseaseObstructive sleep apneanervous system diseasesrespiratory tract diseasesSurgeryObstructive sleep apneaFatty Liver030228 respiratory systemApnea–hypopnea indexLiverLiver steatosiFeasibility Studies030211 gastroenterology & hepatologyFemaleElastographyLongitudinal studySteatosisbusinessBody mass indexUltrasound in medicinebiology
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Cardiovascular Events in Moderately to Severely Obese Obstructive Sleep Apnea Patients on Positive Airway Pressure Therapy.

2016

<b><i>Background:</i></b> In moderately to severely obese patients with obstructive sleep apnea (OSA), the effects of long-term positive airway pressure (PAP) treatment on cardiovascular risk are poorly defined. <b><i>Purpose:</i></b> To assess the effect of continuous positive airway pressure (CPAP) or noninvasive ventilation (NIV) on the occurrence of cardiovascular events in obese OSA patients. <b><i>Methods:</i></b> We performed a noninterventional observational study in obese OSA patients recruited between 2007 and 2010 at the Sleep Center, University of Grenoble, treated with CPAP or NIV, and followed for 5.6 year…

Pulmonary and Respiratory MedicineAdultMalemedicine.medical_treatmentMyocardial Infarctionmacromolecular substancesComorbiditySettore MED/10 - Malattie Dell'Apparato Respiratorio030204 cardiovascular system & hematologySeverity of Illness Index03 medical and health sciences0302 clinical medicineSleep and breathingRisk FactorsSeverity of illnessPositive airway pressuremedicineMyocardial RevascularizationHumansContinuous positive airway pressureMyocardial infarctionAngina UnstableObesityAcute Coronary SyndromeStrokeAgedSleep-disordered breathing · Longitudinal studies · Continuous positive airway pressure · Noninvasive ventilation · PrognosisSleep Apnea ObstructiveContinuous Positive Airway Pressurebusiness.industryArrhythmias CardiacMiddle Agedmedicine.diseaseObesityrespiratory tract diseasesObstructive sleep apneaStroke030228 respiratory systemCardiovascular DiseasesAnesthesiaFemalebusinessRespiration; international review of thoracic diseases
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Incident cardiovascular events in severely obese patients treated with continous positive airway pressure (CPAP)/non invasive ventilation (NIV): A 5.…

2015

it is still debated whether CPAP or non-invasive ventilation (NIV) reduces cardiovascular (CV) risk in morbidly obese patients. Obese subjects affected by obstructive sleep apnea (OSA) or obesity hypoventilation syndrome (OHS) (n=210) were recruited between 2007-2010 in the Sleep Center, Univ. of Grenoble; 152 of them were treated with CPAP or NIV, and regularly followed by a home-care provider (Agir a dom). Patients underwent phone interviews to assess incident CV events during 5.6 years (range 4.0-6.5 yrs) of follow-up. One hundred seventeen patients (63 men) responded to questionnaire, 3 OSA patients died, and 32 declined/were lost to follow-up (response rate 77%). All patients at baseli…

Obesity hypoventilation syndromeResponse rate (survey)medicine.medical_specialtymedicine.diagnostic_testbusiness.industryPhysical examinationmedicine.diseasenervous system diseasesrespiratory tract diseasesSurgeryObstructive sleep apneasymbols.namesakeAnesthesiaPositive airway pressuremedicineBreathingsymbolsRespiratory functionPoisson regressionbusiness4.2 Sleep and Control of Breathing
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Gender-specific anthropometric markers of adiposity, metabolic syndrome and visceral adiposity index (VAI) in patients with obstructive sleep apnea

2013

Obstructive sleep apnea often coexists with visceral adiposity and metabolic syndrome. In this study, we analysed gender-related differences in anthropometrics according to sleep apnea severity and metabolic abnormalities. In addition, the visceral adiposity index, a recently introduced marker of cardiometabolic risk, was analysed. Consecutive subjects with suspected obstructive sleep apnea (n = 528, 423 males, mean age ± standard deviation: 51.3 ± 12.8 years, body mass index: 31.0 ± 6.2 kg m(-2) ) were studied by full polysomnography (apnea-hypopnea index 43.4 ± 27.6 h(-1) ). Variables of general and visceral adiposity were measured (body mass index, neck, waist and hip circumferences, wai…

AdultMalemedicine.medical_specialtyWaistPolysomnographyCognitive NeuroscienceBlood PressurePolysomnographySettore MED/10 - Malattie Dell'Apparato Respiratorioreceiving-operator characteristic curveCardiovascular SystemBody Mass IndexBehavioral NeuroscienceInsulin resistanceInternal medicinemedicineHumansObesityAdiposityMetabolic SyndromeSex CharacteristicsSleep Apnea ObstructiveAnthropometrymedicine.diagnostic_testWaist-Hip Ratiobusiness.industryMetabolic Syndrome XSleep apneaGeneral MedicineSex CharacteristicMiddle Agedmedicine.diseaseObesityrespiratory tract diseasesObstructive sleep apneaEndocrinologyfat distributionBiological MarkerCardiologyFemalewomenWaist CircumferenceInsulin ResistanceMetabolic syndromebusinessBody mass indexBiomarkersHumanJournal of Sleep Research
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Adipose Tissue in Sleep Apnea

2015

Obesity is increasingly recognized as a very complex metabolic state. Besides visceral obesity and white adipose tissue (WAT) function, the most recent studies point to a major metabolic role of brown adipose tissue (BAT) in energy metabolism. Visceral obesity is associated with hypoxia of adipose tissue and inflammation, both these features being also present in patients with obstructive sleep apnea (OSA). Obesity and OSA may share some common pathogenetic mechanisms, since hypoxia and inflammation are major features of OSA as well. However, the unique pattern of intermittent hypoxia occurring in OSA patients during sleep may modify the response of WAT and BAT in both lean and obese subjec…

medicine.medical_specialtyAdipose tissueSleep apneaIntermittent hypoxiaWhite adipose tissueBiologyHypoxia (medical)medicine.diseaserespiratory tract diseasesObstructive sleep apneaSleep deprivationEndocrinologymedicine.anatomical_structureInternal medicineBrown adipose tissuemedicinemedicine.symptom
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Noninvasive evaluation of hepatic steatosis and fibrosis in OSA patients at diagnosis

2012

NONALCOHOLIC FATTY LIVER DISEASE SLEEP APNEASettore MED/10 - Malattie Dell'Apparato Respiratorio
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Adipose tissue in sleep apnea: effects of hypoxia and inflammation

2014

Settore MED/10 - Malattie Dell'Apparato Respiratorioobesity hypoxia HIF-1 pathway VEGF brown adipose tissue
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