0000000001011498
AUTHOR
Alejandro Navarro
Estrategia invasiva en pacientes con diabetes avanzada y síndrome coronario agudo sin elevación del segmento ST. Hallazgos angiográficos y evolución clínica. Resultados del estudio PREDICAR
Introduccion y objetivos La diabetes avanzada se puede asociar con una enfermedad coronaria difusa de dificil revascularizacion. Se estudiaron los hallazgos angiograficos y la evolucion clinica de pacientes con diabetes avanzada (insulinodependencia o mas de 5 anos con farmacos) y sindrome coronario agudo sin elevacion del segmento ST tratados con estrategia invasiva. Metodos Se incluyo a 141 pacientes. En la coronariografia se cuantifico la extension de la enfermedad coronaria mediante un sistema de puntuacion sobre 29 segmentos. Durante 1 ano se recogio el evento combinado de muerte, infarto o reingreso por angina. Resultados La extension de la enfermedad coronaria se asocio con 4 variabl…
Invasive Strategy in Patients With Advanced Diabetes and Non-ST-Segment Elevation Acute Coronary Syndrome. Angiographic Findings and Clinical Follow-Up. PREDICAR Study Results
Introduction and objectives Advanced diabetes can be associated with diffuse coronary artery disease that is difficult to treat by revascularization. We studied angiographic findings and disease progression in patients with advanced diabetes (either insulin-dependent or taking antidiabetic drugs for >5 years) and non-ST-elevation acute coronary syndrome who were being treated using an invasive strategy. Methods The study included 141 patients. The extent of the coronary artery disease was quantified using a score derived from a 29-segment coronary angiogram. The composite endpoint was death, myocardial infarction, or readmission for unstable angina within one year of follow-up. Results The …
Genomic Profiling of Patient-Derived Xenografts for Lung Cancer Identifies B2M Inactivation Impairing Immunorecognition
Abstract Purpose: We aimed to maximize the performance of detecting genetic alterations in lung cancer using high-throughput sequencing for patient-derived xenografts (PDXs). Experimental Design: We undertook an integrated RNA and whole-exome sequencing of 14 PDXs. We focused on the genetic and functional analysis of β2-microglobulin (B2M), a component of the HLA class-I complex. Results: We identified alterations in genes involved in various functions, such as B2M involved in immunosurveillance. We extended the mutational analysis of B2M to about 230 lung cancers. Five percent of the lung cancers carried somatic mutations, most of which impaired the correct formation of the HLA-I complex. …