0000000001031879

AUTHOR

Alba La Sala

showing 15 related works from this author

Clinical implications of airway hyper-responsiveness in COPD

2006

COPD represents one of the leading causes of mortality in the general population. This study aimed at evaluating the relationship between airway hyperresponsiveness (AHR) and COPD and its relevance for clinical practice. We performed a MEDLINE search that yielded a total of 1919 articles. Eligible studies were defined as articles that addressed specific aspects of AHR in COPD, such as prevalence, pathogenesis, or prognosis. AHR appears to be present in at least one out of two individuals with COPD. The occurrence of AHR in COPD is influenced by multiple mechanisms, among which impairment of factors that oppose airway narrowing plays an important role. The main determinants of AHR are reduct…

Pulmonary and Respiratory MedicinePathologymedicine.medical_specialtymedicine.medical_treatmentMEDLINEPopulationReviewsSettore MED/10 - Malattie Dell'Apparato RespiratorioBioinformaticsBronchial Provocation TestsPathogenesisDiagnosis DifferentialMedical Subject HeadingsPulmonary Disease Chronic ObstructivePredictive Value of TestsmedicineRespiratory HypersensitivityCOPDHumansairway smooth muscle aging bronchial obstructioneducationLungAsthmaCOPDeducation.field_of_studyLungbusiness.industryHealth Policyairway hyperresponsivenessSmokingPublic Health Environmental and Occupational HealthGeneral Medicinerespiratory systemmedicine.diseasePrognosisAsthmarespiratory tract diseasesbronchial hyperreactivitymedicine.anatomical_structurePredictive value of testsSmoking cessationbusinessAirwayInternational Journal of Chronic Obstructive Pulmonary Disease
researchProduct

Fever and dyspnoea in a tracheostomised patient

2020

A 65-year-old man was referred for evaluation of acute onset of fever, productive cough and dyspnoea. He had previously received a diagnosis of laryngeal carcinoma, which had been treated with laryngectomy and bilateral laterocervical lymphadenectomy, followed by chemotherapy. He underwent plastic surgery of the laryngocutaneous fistula, and a positron emission tomography (PET)- computed tomography (CT) examination performed during follow-up showed 18-FDG (2-fluoro-2-deoxyd- glucose) lung uptake in the apical right portion. He had a smoking history and his regular medications included dexamethasone, metoclopramide, omeprazole, furosemide, cholecalciferol and pregabalin. He had a history of …

lcsh:RC705-779Pulmonary and Respiratory Medicinemedicine.medical_specialtybusiness.industrylung fibrosisMEDLINECase Reportlcsh:Diseases of the respiratory systemtomographySettore MED/10 - Malattie Dell'Apparato RespiratorioExpert Opinionoilrespiratory tract diseases18Emergency medicineMedicinebusiness
researchProduct

Virtual Multidisciplinary Tumor Boards: A Narrative Review Focused on Lung Cancer

2021

To date, the virtual multidisciplinary tumor boards (vMTBs) are increasingly used to achieve high-quality treatment recommendations across health-care regions, which expands and develops the local MTB team to a regional or national expert network. This review describes the process of lung cancer-specific MTBs and the transition process from face-to-face tumor boards to virtual ones. The review also focuses on the project organization's description, advantages, and disadvantages. Semi-structured interviews identified five major themes for MTBs: current practice, attitudes, enablers, barriers, and benefits for the MTB. MTB teams exhibited positive responses to modeled data feedback. Virtualiz…

Pulmonary and Respiratory MedicineMultidisciplinary tumor boardsTeamworkProcess managementReferralProcess (engineering)Computer sciencemedia_common.quotation_subjectReviewVirtualizationcomputer.software_genremedicine.diseaseOncology networksClinical trialVirtualizationMultidisciplinary approachRespiratory CaremedicineNarrative reviewLung cancerLung cancercomputermedia_commonPulmonary Therapy
researchProduct

How Effective and Safe Is Bronchial Thermoplasty in “Real Life” Asthmatics Compared to Those Enrolled in Randomized Clinical Trials?

2016

There is limited information on the efficacy and safety of bronchial thermoplasty (BT) inreal life. We evaluated the outcomes of the randomized clinical trials for BT in severe asthmatics, in whom the exclusion criteria were not strictly controlled. A case series of seven asthmatics (M/F: 4/3; age:54.6±2.9years) is reported. Subjects had a statistically significant improvement in AQLQ (from a mean of3.96±1.1to4.5±1.2and5.5±0.6after 6 and 12 months of treatment;p=0.0007) and in the ACQ score (from2.77±0.8to1.83±1.2and1.5±0.8after 6 and 12 months;p<0.001). In the year after BT, severe exacerbations, salbutamol use, and OCS use were significantly lower compared with the 1-yr pretreatment pe…

Pediatricsmedicine.medical_specialtyPretreatment PeriodArticle SubjectMEDLINElcsh:MedicineSettore MED/10 - Malattie Dell'Apparato RespiratorioGeneral Biochemistry Genetics and Molecular Biologylaw.invention03 medical and health sciences0302 clinical medicineRandomized controlled triallawInternal medicineMedicineIn real life030212 general & internal medicineBronchial ThermoplastyGeneral Immunology and MicrobiologyBronchial thermoplastybusiness.industrylcsh:RGeneral MedicineAsthma030228 respiratory systemClinical StudySalbutamolbusinessmedicine.drugBioMed Research International
researchProduct

The airway response to deep inspirations decreases with COPD severity and is associated with airway distensibility assessed by computed tomography.

2008

In patients with mild chronic obstructive pulmonary disease (COPD), the effect of deep inspirations (DIs) to reverse methacholine-induced bronchoconstriction is largely attenuated. In this study, we tested the hypothesis that the effectiveness of DI is reduced with increasing disease severity and that this is associated with a reduction in the ability of DI to distend the airways. Fifteen subjects [Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage I–II: n = 7; GOLD stage III–IV: n = 8] underwent methacholine bronchoprovocation in the absence of DI, followed by DI. The effectiveness of DI was assessed by their ability to improve inspiratory vital capacity and forced expira…

SpirometryHigh-resolution computed tomographyPhysiologyRespiratory SystemVital CapacityHyperinflationSettore MED/10 - Malattie Dell'Apparato RespiratorioSeverity of Illness IndexBronchial Provocation TestsBronchoconstrictor AgentsAirway-parenchyma interdependencePulmonary Disease Chronic ObstructiveBronchoprovocationPhysiology (medical)Forced Expiratory VolumeSeverity of illnessAdministration InhalationmedicineHumansHigh-resolution computed tomographyMethacholine ChlorideAgedAged 80 and overCOPDMethacholinemedicine.diagnostic_testbusiness.industryAirway-parenchyma interdependence; Bronchoprovocation; High-resolution computed tomography; Hyperinflation; Methacholine; Administration Inhalation; Aged; Aged 80 and over; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Elasticity; Forced Expiratory Volume; Humans; Methacholine Chloride; Middle Aged; Pulmonary Disease Chronic Obstructive; Respiratory System; Severity of Illness Index; Spirometry; Vital Capacity; Inhalation; Tomography Spiral Computed; Physiology; Physiology (medical)Respiratory diseaseArticlesrespiratory systemMiddle Agedmedicine.diseaseElasticityrespiratory tract diseasesBronchial Provocation TestInhalationSpirometryAnesthesiaBronchoconstrictor AgentBronchoconstrictionMethacholinemedicine.symptomBronchial HyperreactivityAirwaybusinessTomography Spiral ComputedHumanmedicine.drugJournal of applied physiology (Bethesda, Md. : 1985)
researchProduct

The Attenuation of the Bronchodilatory Effect of Deep Inspiration (DI) in COPD Is Related to Reduced Airway Distensibility as Measured by HRCT

2005

methacholine imaging bronchial obstructionSettore MED/10 - Malattie Dell'Apparato Respiratorio
researchProduct

Airway wall thickness by HRCT in patients with COPD.

2008

airway HRCT COPD
researchProduct

The loss of the beneficial effect of deep inspiration (DI) in COPD is associated with severity of disease

2007

lung inflation methacholine bronchial obstructionSettore MED/10 - Malattie Dell'Apparato Respiratorio
researchProduct

Valutazione dell’efficacia e della sicurezza dei sistemi di riduzione endoscopica di volume polmonare nel trattamento dell’enfisema polmonare

2014

BRONCOSCOPIA ENFISEMA VENTILAZIONE COLLATERALE
researchProduct

Valutazione della riduzione della distensibilità delle vie aeree in relazione alla gravità del quadro di broncopneumopatia cronica ostruttiva mediant…

2008

HRTC BPCO bronchiSettore MED/10 - Malattie Dell'Apparato Respiratorio
researchProduct

L’iperreattività bronchiale e la BPCO nel paziente anziano

2006

metacolina invecchiamentoSettore MED/10 - Malattie Dell'Apparato Respiratorio
researchProduct

Airway distensibility by HRCT decreases with severity of COPD.

2008

COPD airways HRCTSettore MED/10 - Malattie Dell'Apparato Respiratorio
researchProduct

Airway Distensibility by HRCT in COPD Patients

2006

lung inflation bronchial obstruction methacholineSettore MED/10 - Malattie Dell'Apparato Respiratorio
researchProduct

Lung hyperinflation in COPD attenuates airway distension by deep inspiration (DI) measured with HRCT

2005

imaging lung inflationSettore MED/10 - Malattie Dell'Apparato Respiratorio
researchProduct

Virtual Multidisciplinary Tumor Board: A Narrative Review Focused on Lung Cancer

2021

Article full text The above summary slide represents the opinions of the authors. For a full list of declarations, including funding and author disclosure statements, please see the full text online (see “read the peer-reviewed publication” opposite). © The authors, CC-BY-NC 2021.

researchProduct