Apolipoprotein AI and HDL are reduced in stable cirrhotic patients with adrenal insufficiency: a possible role in glucocorticoid deficiency

Backgrounds and aims: Adrenal insufficiency (AI) has been reported in patients with stable cirrhosis. A lack of substrates has been suggested as a possible contributing pathogenic mechanism leading to glucocorticoid deficiency in these subjects. To better explore this hypothesis, we studied lipoproteins in cirrhotics with and without AI. Methods. A total of 81 cirrhotic patients and 30 normal volunteers were enrolled. The severity of liver disease was graded by Child-Pugh score. Total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride (TG), and apolipoprotein AI (Apo-AI) levels were evaluated. HDL subfractions were measured by gradient gel electrop…

Serum coding and non-coding RNAs as biomarkers of NAFLD and fibrosis severity

Background & Aims: In patients with non-alcoholic fatty liver disease (NAFLD), liver biopsy is the gold standard to detect non-alcoholic steatohepatitis (NASH) and stage liver fibrosis. We aimed to identify differentially expressed mRNAs and non-coding RNAs in serum samples of biopsy-diagnosed mild and severe NAFLD patients with respect to controls and to each other. Methods: We first performed a whole transcriptome analysis through microarray (n = 12: four Control: CTRL; four mild NAFLD: NAS ≤ 4 F0; four severe NAFLD NAS ≥ 5 F3), followed by validation of selected transcripts through real-time PCRs in an independent internal cohort of 88 subjects (63 NAFLD, 25 CTRL) and in an external …

Series arc faults in AC and DC electrical circuits. Characterization and detection methods

This paper analyzes the problem of the arc faults in both AC and DC low voltage electrical circuits. The state-of-the-art of the arc fault detection methods is analyzed together with the UL 1699 and UL 1699B Standard requirements for protection devices against arc faults (AFCIs). An experimental characterization is carried out of the arc fault phenomenon, for both AC and DC systems, focusing the attention on series arcs. The experimental measurements are carried out on a proper test bench, which has been developed in order to reproduce significant arcing conditions, in accordance with the UL 1699 Standard requirements.

Caratterizzazione e metodi di riconoscimento degli arc faults per applicazioni in sistemi di bassa tensione

Dangerous effects induced on power MOSFETs by terrestrial neutrons: A theoretical study and an empirical approach based on accelerated experimental analysis

This paper investigates the effects that terrestrial neutrons can induce on power MOSFETs when they are biased during their normal working conditions especially in inverters for photovoltaic applications. After a brief review of power MOSFETs failure phenomena caused by neutron irradiation (with emphasis on so called “Single Event Effects” (SEE)), the results of an accelerated test performed with the Am-Be source at the University of Palermo are discussed.

Serum coding and non-coding RNAs as biomarkers of NAFLD and fibrosis severity

Background: In patients with NAFLD liver biopsy is the gold standard to detect NASH and stage liver fibrosis. We aimed to identify differentially expressed mRNAs and non-coding RNAs in serum samples of biopsy-diagnosed mild and severe NAFLD patients with respect to controls and to each other. Methods: We first performed a whole transcriptome analysis through microarray (n=12: 4 CTRL; 4 mild NAFLD: NAS≤4 F0; 4 severe NAFLD NAS≥5 F3), followed by validation of selected transcripts through qPCRs in 88 subjects: 63 NAFLD, 25 CTRL. A similar analysis was also performed on HepG2 exposed to Oleate:Palmitate or only Palmitate (cellular model of NAFL/NASH) at intracellular/extracellular levels. Tran…

Use of 70 MeV proton beam for medical applications at INFN-LNS: CATANA project

The project CATANA (Centro di Adro Terapia ed Applicazioni Nucleari Avanzate) is a collaboration between the INFN-Laboratori Nazionali del Sud (LNS), Physics Department, Ophthalmology Institute and Radiology Institute of the Catania University and CSFNSM Catania. The main goal of CATANA is the study and the application of protontherapy for the treatment of shallow tumors (4 cm max) like uveal melanomas and subfoveal macular degenerations.

A set of indicators for arc faults detection based on low frequency harmonic analysis

In this paper a novel set of indicators is presented for arc faults detection in electrical circuits. The indicators are defined starting from an experimental characterization of the arc fault phenomenon and the study of the arcing current in several test conditions, which were chosen in accordance with the UL 1699 Standard requirements. The proposed parameters are measured by means of a high resolution low frequency spectral analysis of the arcing current, which allows to achieve a good spectral resolution even with short observation windows.