0000000001048715
AUTHOR
Marco Fiore
showing 30 related works from this author
Health-Related Quality of Life Issues Experienced by Thoracic and Breast Sarcoma Patients: A Rare and Understudied Group
2021
Thoracic and breast sarcomas constitute a rare subgroup within the sarcoma population. There is limited knowledge about their health-related quality of life (HRQoL) and a valid disease-specific HRQoL instrument is lacking. This qualitative study aimed to investigate the HRQoL issues experienced by a small group of thoracic and breast sarcoma patients. Semi-structured interviews with 19 thoracic and four breast sarcoma patients were conducted and thematically analysed. Physical issues mentioned by both groups were fatigue, sleep disturbances, pain, wound infections, and symptoms related to chemotherapy and radiotherapy. Tightness in the back and restrictions in performing tasks above arm hei…
Amplitude analysis ofB0→D¯0K+π−decays
2015
The Dalitz plot distribution of B-0 -> (D) over bar K-0(+)pi(-) decays is studied using a data sample corresponding to 3.0 fb(-1) of pp collision data recorded by the LHCb experiment during 2011 and 2012. The data are described by an amplitude model that contains contributions from intermediate K* (892)(0), K*(1410)(0), K-2*(1430)(0) and D-2(*)(2460)(-) resonances. The model also contains components to describe broad structures, including the K-0(*)(1430)(0) and D-0(*)(2400)(-) resonances, in the K pi S-wave and the D pi S-and P-waves. The masses and widths of the D-0*(2400)(-) and D-2(*)(2460)(-) resonances are measured, as are the complex amplitudes and fit fractions for all components in…
Model-Independent Evidence forJ/ψpContributions toΛb0→J/ψpK−Decays
2016
The data sample of Lambda(0)(b) -> J/psi pK(-) decays acquired with the LHCb detector from 7 and 8 TeV pp collisions, corresponding to an integrated luminosity of 3 fb(-1), is inspected for the presence of J/psi p or J/psi K- contributions with minimal assumptions about K(-)p contributions. It is demonstrated at more than nine standard deviations that Lambda(0)(b) -> J/psi pK(-) decays cannot be described with K- p contributions alone, and that J/psi K- contributions play a dominant role in this incompatibility. These model-independent results support the previously obtained model-dependent evidence for P-c(+)-> J/psi p charmonium-pentaquark states in the same data sample.
Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 count…
2022
© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index to support local elective surgical system strengthening and address growing backlogs. Methods: First, we performed an international consultation through a four-stage consensus process to develop a multidomain index for hospital-level assess…
Search for Hidden-Sector Bosons inB0→K*0μ+μ−Decays
2015
A search is presented for hidden-sector bosons, $\chi$, produced in the decay ${B^0\!\to K^*(892)^0\chi}$, with $K^*(892)^0\!\to K^{+}\pi^{-}$ and $\chi\!\to\mu^+\mu^-$. The search is performed using $pp$-collision data corresponding to 3.0 fb$^{-1}$ collected with the LHCb detector. No significant signal is observed in the accessible mass range $214 \leq m({\chi}) \leq 4350$ MeV, and upper limits are placed on the branching fraction product $\mathcal{B}(B^0\!\to K^*(892)^0\chi)\times\mathcal{B}(\chi\!\to\mu^+\mu^-)$ as a function of the mass and lifetime of the $\chi$ boson. These limits are of the order of $10^{-9}$ for $\chi$ lifetimes less than 100 ps over most of the $m(\chi)$ range, a…
Ceftolozane-Tazobactam Combination Therapy Compared to Ceftolozane-Tazobactam Monotherapy for the Treatment of Severe Infections: A Systematic Review…
2021
Ceftolozane-tazobactam (C/T) is a combination of an advanced-generation cephalosporin (ceftolozane) with a &beta
First observation of the rareB+→D+K+π−decay
2016
The B+→D+K+π- decay is observed in a data sample corresponding to 3.0 fb-1 of pp collision data recorded by the LHCb experiment during 2011 and 2012. The signal significance is 8σ and the branching fraction is measured to be B(B+→D+K+π-)=(5.31±0.90±0.48±0.35)×10-6, where the uncertainties are statistical, systematic and due to the normalization mode B+→D-K+π+, respectively. The Dalitz plot appears to be dominated by broad structures. Angular distributions are exploited to search for quasi-two-body contributions from B+→D2∗(2460)0K+ and B+→D+K∗(892)0 decays. No significant signals are observed and upper limits are set on their branching fractions.
Intraoperative positive end-expiratory pressure and postoperative pulmonary complications: a patient-level meta-analysis of three randomised clinical…
2022
BACKGROUND: High intraoperative PEEP with recruitment manoeuvres may improve perioperative outcomes. We re-examined this question by conducting a patient-level meta-analysis of three clinical trials in adult patients at increased risk for postoperative pulmonary complications who underwent non-cardiothoracic and non-neurological surgery. METHODS: The three trials enrolled patients at 128 hospitals in 24 countries from February 2011 to February 2018. All patients received volume-controlled ventilation with low tidal volume. Analyses were performed using one-stage, two-level, mixed modelling (site as a random effect; trial as a fixed effect). The primary outcome was a composite of postoperati…
First experimental study of photon polarization in radiative B0s decays.
2017
The polarization of photons produced in radiative $B^{0}_{s}$ decays is studied for the first time. The data are recorded by the LHCb experiment in $pp$ collisions corresponding to an integrated luminosity of 3fb$^{-1}$ at center-of-mass energies of $7$ and $8$TeV. A time-dependent analysis of the $B^{0}_{s} \to \phi \gamma$ decay rate is conducted to determine the parameter ${\mathcal{A}}^\Delta$, which is related to the ratio of right- over left-handed photon polarization amplitudes in $b \to s \gamma$ transitions. A value of ${\mathcal{A}}^\Delta=-0.98^{\,+0.46\,+0.23}_{\,-0.52\,-0.20}$ is measured. This result is consistent with the Standard Model prediction within two standard deviatio…
Observation ofJ/ψpResonances Consistent with Pentaquark States inΛb0→J/ψK−pDecays
2015
Observations of exotic structures in the J/ψp channel, that we refer to as pentaquark-charmonium states, in Λ0b→J/ψK−p decays are presented. The data sample corresponds to an integrated luminosity of 3/fb acquired with the LHCb detector from 7 and 8 TeV pp collisions. An amplitude analysis is performed on the three-body final-state that reproduces the two-body mass and angular distributions. To obtain a satisfactory fit of the structures seen in the J/ψp mass spectrum, it is necessary to include two Breit-Wigner amplitudes that each describe a resonant state. The significance of each of these resonances is more than 9 standard deviations. One has a mass of 4380±8±29 MeV and a width of 205±1…
Unravelling the heterogeneity of soft tissue and bone sarcoma patients’ health-related quality of life: a systematic literature review with focus on …
2020
Contains fulltext : 229532.pdf (Publisher’s version ) (Open Access) Patients with sarcoma experience many physical and psychological symptoms, adversely affecting their health-related quality of life (HRQoL). HRQoL assessment is challenging due to the diversity of the disease. This review aims to unravel the heterogeneity of HRQoL of patients with sarcoma with regard to tumour location and to summarise the used measures in research. English-language literature from four databases published between January 2000 and April 2019 was reviewed. Studies that described adult sarcoma HRQoL outcomes were included and classified according to primary sarcoma location. Eighty-seven articles met the incl…
Measurement of the Ratio of Branching FractionsB(B¯0→D*+τ−ν¯τ)/B(B¯0→D*+μ−ν¯μ)
2015
The branching fraction ratio R(D-*) = B((B) over bar (0) -> D-*(+)tau(-)(nu) over bar (tau))/B((B) over bar (0) -> D-*(+)mu(-)(nu) over bar (mu)) is measured using a sample of proton-proton collision data corresponding to 3.0 fb(-1) of integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The tau lepton is identified in the decay mode tau(-) -> mu(-)(nu) over bar (mu)nu(tau). The semitauonic decay is sensitive to contributions from non-standard-model particles that preferentially couple to the third generation of fermions, in particular, Higgs-like charged scalars. A multidimensional fit to kinematic distributions of the candidate (B) over bar (0) decays gives R(D-*) =…
Measurements of the Λb0→J/ψΛ decay amplitudes and the Λb0 polarisation in pp collisions at s=7 TeV
2013
An angular analysis of Λ0b→J/ψΛ decays is performed using a data sample corresponding to 1.0 fb−1 collected in pp collisions at √s=7 TeV with the LHCb detector at the LHC. A parity violating asymmetry parameter characterising the Λ0b→J/ψΛ decay of 0.05±0.17±0.07 and a Λ0b transverse production polarisation of 0.06±0.07±0.02 are measured, where the first uncertainty is statistical and the second systematic.
Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study
2021
We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26…
Quantum numbers of theX(3872)state and orbital angular momentum in itsρ0J/ψdecay
2015
Angular correlations in B+→X(3872)K+ decays, with X(3872)→ρ0J/ψ, ρ0→π+π− and J/ψ→μ+μ−, are used to measure orbital angular momentum contributions and to determine the JPC value of the X(3872) meson. The data correspond to an integrated luminosity of 3.0 fb−1 of proton-proton collisions collected with the LHCb detector. This determination, for the first time performed without assuming a value for the orbital angular momentum, confirms the quantum numbers to be JPC=1++. The X(3872) is found to decay predominantly through S wave and an upper limit of 4% at 95% C.L. is set on the fraction of D wave.
Risks and benefits of animal-assisted interventions for critically ill patients admitted to intensive care units
2023
Abstract Background Pets offer significant health benefits, from decreased cardiovascular risks to anxiety and post-traumatic stress improvements. Animal-assisted interventions (AAI) are not frequently practiced in the intensive care unit (ICU) for fear of health risk for critical patients because there is a hypothetical risk of zoonoses. Objectives This systematic review aimed to collect and summarize available evidence about AAI in the ICU. The Review questions were “Do AAI improve the clinical outcome of Critically Ill Patients admitted to ICUs?” and “Are the zoonotic infections the cause of negative prognosis?”. Methods The following databases were searched on 5 January 2023: Cochrane C…
Amplitude analysis ofB+→J/ψϕK+decays
2017
The first full amplitude analysis of B+→J/ψϕK+ with J/ψ→μ+μ−, ϕ→K+K− decays is performed with a data sample of 3 fb−1 of pp collision data collected at s√=7 and 8 TeV with the LHCb detector. The data cannot be described by a model that contains only excited kaon states decaying into ϕK+, and four J/ψϕ structures are observed, each with significance over 5 standard deviations. The quantum numbers of these structures are determined with significance of at least 4 standard deviations. The lightest is best described as a D±sD∗∓s cusp, but a resonant interpretation is also possible with mass consistent with, but width much larger than, previous measurements of the claimed X(4140) state. The mode…
Measurement of the Difference of Time-IntegratedCPAsymmetries inD0→K−K+andD0→π−π+Decays
2016
A search for CP violation in $D^0 \rightarrow K^{-} K^{+} $ and $D^0 \rightarrow \pi^{-} \pi^{+} $ decays is performed using $pp$ collision data, corresponding to an integrated luminosity of $3~fb^{-1}$, collected using the LHCb detector at centre-of-mass energies of 7 and $8~$TeV. The flavour of the charm meson is inferred from the charge of the pion in $D^{*+}\rightarrow D^0\pi^+$ and $D^{*-}\rightarrow \bar{D^0}\pi^{-}$ decays. The difference between the CP asymmetries in $D^0 \rightarrow K^{-} K^{+} $ and $D^0 \rightarrow \pi^{-} \pi^{+} $ decays, $\Delta A_{CP} \equiv A_{CP}(K^{-} K^{+}) - A_{CP}(\pi^{-} \pi^{+})$, is measured to be $\left( -0.10 \pm 0.08(stat) \pm 0.03(syst) \right) \…
Ceftazidime-Avibactam Combination Therapy Compared to Ceftazidime-Avibactam Monotherapy for the Treatment of Severe Infections Due to Carbapenem-Resi…
2020
Ceftazidime-avibactam (CZA) is a novel beta-lactam beta-lactamase inhibitor combination approved for the treatment of complicated urinary tract infections, complicated intra-abdominal infections, and for hospital-acquired/ventilator-associated pneumonia. The aim of this systematic review (PROSPERO registration number: CRD42019128927) was to evaluate the effectiveness of CZA combination therapy versus CZA monotherapy in the treatment of severe infections. The databases included in the search, until February 12th, 2020, were MEDLINE by PubMed, EMBASE, and The Cochrane Central Register of Controlled Trials. We included both randomized controlled trials (RCTs) and non-randomized studies publish…
Amplitude analysis ofB−→D+π−π−decays
2016
The Dalitz plot analysis technique is used to study the resonant substructures of $B^{-} \to D^{+} \pi^{-} \pi^{-}$ decays in a data sample corresponding to 3.0 ${\rm fb}^{-1}$ of $pp$ collision data recorded by the LHCb experiment during 2011 and 2012. A model-independent analysis of the angular moments demonstrates the presence of resonances with spins 1, 2 and 3 at high $D^{+}\pi^{-}$ mass. The data are fitted with an amplitude model composed of a quasi-model-independent function to describe the $D^{+}\pi^{-}$ S-wave together with virtual contributions from the $D^{*}(2007)^{0}$ and $B^{*0}$ states, and components corresponding to the $D^{*}_{2}(2460)^{0}$, $D^{*}_{1}(2680)^{0}$, $D^{*}_…
Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study
2021
This international, prospective, cohort study enrolled 20 006 adult (≥18 years) patients from 466 hospitals in 61 countries with 15 cancer types, who had a decision for curative surgery during the COVID-19 pandemic and were followed up until the point of surgery or cessation of follow-up (Aug 31, 2020). Average national Oxford COVID-19 Stringency Index scores were calculated to define the government response to COVID-19 for each patient for the period they awaited surgery, and classified into light restrictions (index 60). The primary outcome was the non-operation rate (defined as the proportion of patients who did not undergo planned surgery). Cox proportional-hazards regression models wer…
Observation of Bc+→J/ψD(*)K(*) decays
2017
A search for the decays B + c → J / ψ D ( * ) 0 K + and B + c → J / ψ D ( * ) + K * 0 is performed with data collected at the LHCb experiment corresponding to an integrated luminosity of 3 fb − 1 . The decays B + c → J / ψ D 0 K + and B + c → J / ψ D * 0 K + are observed for the first time, while first evidence is reported for the B + c → J / ψ D * + K * 0 and B + c → J / ψ D + K * 0 decays. The branching fractions of these decays are determined relative to the B + c → J / ψ π + decay. The B + c mass is measured, using the J / ψ D 0 K + final state, to be 6274.28 ± 1.40 ( stat ) ± 0.32 ( syst ) MeV / c 2 . This is the most precise single measurement of the B + c mass to date.
Study of J/ψ Production in Jets
2017
The production of $J/\psi$ mesons in jets is studied in the forward region of proton-proton collisions using data collected with the LHCb detector at a center-of-mass energy of 13 TeV. The fraction of the jet transverse momentum carried by the $J/\psi$ meson, $z \equiv p_{\rm T}(J/\psi)/p_{\rm T}({\rm jet})$, is measured using jets with $p_{\rm T}({\rm jet}) > 20$ GeV in the pseudorapidity range $2.5 < \eta({\rm jet}) < 4.0$. The observed $z$ distribution for $J/\psi$ mesons produced in $b$-hadron decays is consistent with expectations. However, the results for prompt $J/\psi$ production do not agree with predictions based on fixed-order non-relativistic QCD. This is the first measurement o…
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
2023
Background: Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods: This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, r…
Head and neck cancer surgery during the COVID-19 pandemic: An international, multicenter, observational cohort study
2020
Background The aims of this study were to provide data on the safety of head and neck cancer surgery currently being undertaken during the coronavirus disease 2019 (COVID-19) pandemic. Methods This international, observational cohort study comprised 1137 consecutive patients with head and neck cancer undergoing primary surgery with curative intent in 26 countries. Factors associated with severe pulmonary complications in COVID-19-positive patients and infections in the surgical team were determined by univariate analysis. Results Among the 1137 patients, the commonest sites were the oral cavity (38%) and the thyroid (21%). For oropharynx and larynx tumors, nonsurgical therapy was favored in…
SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study
2021
SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 da…
Early outcomes and complications following cardiac surgery in patients testing positive for coronavirus disease 2019: An international cohort study
2021
The outbreak of severe acute respiratory syndromecoronavirus-2, the cause of coronavirus disease 2019 (COVID-19) in December 2019 represented a global emergency accounting for more than 2.5 million deaths worldwide.1 It has had an unprecedented influence on cardiac surgery internationally, resulting in cautious delivery of surgery and restructuring of services.2 Understanding the influence of COVID-19 on patients after cardiac surgery is based on assumptions from other surgical specialties and single-center studies. The COVIDSurg Collaborative conducted a multicenter cohort study, including 1128 patients, across 235 hospitals, from 24 countries demonstrating perioperative COVID-19 infection…
Observation of the rare B(s)(0) + decay from the combined analysis of CMS and LHCb data.
2015
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported licence.-- et al.
Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score
2021
The British journal of surgery 108(11), 1274-1292 (2021). doi:10.1093/bjs/znab183
Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pand…
2021
Abstract Background Surgical services are preparing to scale up in areas affected by COVID-19. This study aimed to evaluate the association between preoperative SARS-CoV-2 testing and postoperative pulmonary complications in patients undergoing elective cancer surgery. Methods This international cohort study included adult patients undergoing elective surgery for cancer in areas affected by SARS-CoV-2 up to 19 April 2020. Patients suspected of SARS-CoV-2 infection before operation were excluded. The primary outcome measure was postoperative pulmonary complications at 30 days after surgery. Preoperative testing strategies were adjusted for confounding using mixed-effects models. Results Of 8…