0000000001052483
AUTHOR
Pietro Alimondi
IL vaccino quadrivalente anti-HPV: efficacia e sicurezza.
La prevalenza globale del Papillomavirus (HPV) nelle neoplasie cervicali è maggiore del 90%. Il 70% delle donne si espone all'infezione da HPV almeno una volta nella vita: una su cinque può sviluppare il cancro. Il vaccino quadrivalente anti HPV 16, 18, 6 e 11 Sanofi Pasteur MSD (GARDASIL) ad azione profilattica ha come target il 70% dei casi di CIN 2/3 e di cancro cervicale, il 90% dei casi di condilomi genitali, il 30-35% dei casi di CIN. L'efficacia del vaccino è stata valutata in 4 studi clinici di fase II e III, randomizzati, in doppio cieco, verso placebo, che hanno coinvolto un totale di 20.583 donne dai 16 ai 26 anni d'età. I risultati di questo studio a 3 anni dalla sommministrazio…
Early onset Mirror Syndrome associated with foetal sacrococcigeal teratoma: a rare entity
In the mirror syndrome, maternal symptoms mime foetal and placental oedema. The pathogenesis is unknown. The most common etiologic associations are rhesus isoimmunization, twin-twin transfusion syndrome and viral infections. Few reports are associated to foetal tumors and particularly to sacroccoccigeal teratoma (SCT). Based on several published series, foetal SCT with placentomegaly and hydrops is almost universally fatal; foetal surgery is not typically offered for hydropic foetuses beyond 26 weeks of gestational age. Delivery of the foetus is the choise treatment when mirror syndrome is present with supporting the pregnancy until delivery is necessary for maternal indications or the foet…
Reproductive outcomes in couples affected by human papillomavirus infection undergoing in vitro fertilization procedures
Reproductive outcomes in couples affected by human papillomavirus infection undergoing in vitro fertilization procedures G. Ruvolo1, L. Giovannelli2, R. Schillaci3, P. Alimondi3, A. Pane1, A. Perino3, E. Cittadini1 1Centro di Biologia della Riproduzione, Centro di Biologia della Riproduzione, Palermo, Italy 2Dipartimento di Scienze per la Promozione della Salute, Dipartimento di Scienze per la Promozione della Salute, Palermo, Italy 3Dipartimento Materno Infantile University of Palermo, Dipartimento Materno Infantile University of Palermo, Palermo, Italy Introduction: Genital human papillomavirus (HPV) infection is the most common sexually transmitted viral infection worldwide, and has been…
Human papillomavirus infection in couples undergoing in vitro fertilization procedures: impact on reproductive outcomes.
A prospective study was performed to assess the relationship between human papillomavirus (HPV) infection in 199 infertile couples and outcome of assisted reproductive technologies (ARTs). A highly statistically significant correlation between pregnancy loss rate (proportion of pregnancies detected by β-hCG that did not progress beyond 20 weeks) and positive HPV DNA testing in the male partner of infertile couples, compared with HPV negatives, was observed (66.7% vs. 15%).