0000000001053521
AUTHOR
N. Yanaihara
Peptidergic Innervation in Chronic Pancreatitis
The reason for the generation and continuation of chronic pain in chronic pancreatitis is unclear [6, 10, 11, 13, 61, 117]. Current concepts of the neurobiology of pain point to the possible role of various neuropeptides in pain processing and inflammation [8, 29, 32, 33, 44, 60, 64, 65, 68, 79, 104, 112]. A key function has been ascribed to the proinflammatory and pronociceptive peptides of the tachykininin (TK) family (8, 44, 104, 109]. That the tachykinin substance P (SP) may be involved in chronic inflammatory and painful disease of the gastrointestinal system is evidenced by a selective increase in the density of tachykinin receptors in the bowels of patients suffering from Crohn’s dis…
Distribution of Met-enkephalyl-Arg-Gly-Leu in rat larynx: partial coexistence with vasoactive intestinal polypeptide, peptide histidine isoleucine and neuropeptide Y.
Abstract Using light microscopic (LM) enzyme-immunohistochemistry on deparaffinized adjacent sections Met-enkephalyl-Arg-Gly-Leu (ME-RGL) immunoreactivity was found to partially coexist with immunoreactive neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP) and peptide histidine isoleucine (PHI) in intrinsic laryngeal neurons of the rat. Further ME-RGL-immunoreactive (ir) fibres were found around glands in the subepithelium, in connective tissue of striated muscle and in the perichondrium, as well as around arterial and venous blood vessels. They frequently contacted mast cells and macrophages. The presence of ME-RGL indicates pro-enkephalin-related origin of this novel laryngeal …