6533b85afe1ef96bd12b8ae4

RESEARCH PRODUCT

Peptidergic Innervation in Chronic Pancreatitis

H.j. ZentelMarkus W. BüchlerN. YanaiharaEberhard WeiheHelmut FriessS. Müller

subject

medicine.medical_specialtybusiness.industryChronic painInflammationSubstance PDiseasemedicine.diseaseGastroenterologyUlcerative colitisProinflammatory cytokinechemistry.chemical_compoundchemistryInternal medicinemedicinePancreatitismedicine.symptombusinessTachykinin receptor

description

The reason for the generation and continuation of chronic pain in chronic pancreatitis is unclear [6, 10, 11, 13, 61, 117]. Current concepts of the neurobiology of pain point to the possible role of various neuropeptides in pain processing and inflammation [8, 29, 32, 33, 44, 60, 64, 65, 68, 79, 104, 112]. A key function has been ascribed to the proinflammatory and pronociceptive peptides of the tachykininin (TK) family (8, 44, 104, 109]. That the tachykinin substance P (SP) may be involved in chronic inflammatory and painful disease of the gastrointestinal system is evidenced by a selective increase in the density of tachykinin receptors in the bowels of patients suffering from Crohn’s disease and ulcerative colitis [62, 63, 64].

yearjournalcountryeditionlanguage
1990-01-01
https://doi.org/10.1007/978-3-642-75319-0_11