Transcriptome and computational analysis assess the anti-tubulin activity of [1,2]oxazole derivatives in lymphoma

Synthesis and antiproliferative activity of [1,2,4] triazino[4,3-a]indoles

A series of [1, 2, 4triazino[4,3-a]indoles was prepared in good yield by reacting 2-diazo-3-ethoxycarbonylindole with methylene active compounds. Derivatives of the title ring system were tested against a panel of 60 human tumor cell lines, and showed inhibitory activity against a wide range of cancer cell lines at micromolar concentration.