0000000001162697

AUTHOR

Istvan Boldogh

showing 3 related works from this author

Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

2018

Abstract It has been suggested that exercise training and probiotic supplementation could decelerate the progress of functional and biochemical deterioration in APP/PS1 transgenic mice (APP/PS1TG). APP/PS1TG mice were subjected to exercise training and probiotic treatments and functional, biochemical and microbiome markers were analyzed. Under these conditions the mice significantly outperformed controls on The Morris Maze Test, and the number of beta-amyloid plaques decreased in the hippocampus. B. thetaiotaomicron levels correlated highly with the results of the Morris Maze Test (p

Male0301 basic medicineGenetically modified mouseAgingalzheimer; exercise; microbiome; probioticsalzheimermicrobiomeMice TransgenicPlaque AmyloidDiseaseHippocampusBiochemistrylaw.inventionAmyloid beta-Protein PrecursorMice03 medical and health sciencesProbiotic0302 clinical medicineEndocrinologyAlzheimer DiseaselawPhysical Conditioning Animalmental disordersPresenilin-1GeneticsAnimalsHippocampus (mythology)MedicineMicrobiomeMolecular BiologyAmyloid beta-Peptidesexercisebusiness.industryMicrobiotaCell BiologyDisease Models Animal030104 developmental biologyprobioticsImmunologybusiness030217 neurology & neurosurgeryExperimental Gerontology
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The COVID-19 pandemic and physical activity

2020

The SARS-CoV-2-caused COVID-19 pandemic has resulted in a devastating threat to human society in terms of health, economy, and lifestyle. Although the virus usually first invades and infects the lung and respiratory track tissue, in extreme cases, almost all major organs in the body are now known to be negatively impacted often leading to severe systemic failure in some people. Unfortunately, there is currently no effective treatment for this disease. Pre-existing pathological conditions or comorbidities such as age are a major reason for premature death and increased morbidity and mortality. The immobilization due to hospitalization and bed rest and the physical inactivity due to sustained…

Agingmedicine.medical_specialtyCoronavirus disease 2019 (COVID-19)medicine.medical_treatmentPhysical activityPhysical Therapy Sports Therapy and RehabilitationDiseaseCardiovascularBed restArticlelaw.inventionlawPandemicQuarantinemedicineOrthopedics and Sports MedicineIntensive care medicinePathologicalNutritionlcsh:R5-920Lungbusiness.industrySettore MED/09 - MEDICINA INTERNABrainCOVID-19Immunemedicine.anatomical_structureRespiratoryMusclelcsh:Medicine (General)Physical InactivitybusinessSports Medicine and Health Science
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Inducible Responses and Protective Functions of Mammalian Cells Upon Exposure to UV Light and Ionizing Radiation

1999

In mammalian cells, ultraviolet (UV) light as well as ionizing radiation (IR) transcriptionally activate the early-responsive genes c-fos, c jun,junB and junD. The induction of fos and jun by UV-C is currently understood to occur via activation of the EGF receptor and the Ras, Raf, ERK and JNK cascade leading ultimately to phosphorylation of transcription factors such as Fos and Jun (AP-1). This, finally, gives rise to transcriptional activation of AP-1 dependent target genes. Another gene we have recently demonstrated to be immediate-early inducible upon UV-irradiation encodes the Ras-related small GTPase RhoB. The pathway of rhoB induction appears to be different from fos/jun because (i) …

MAPK/ERK pathwayMutationChemistryDNA repairJUNBDNA damageRHOBc-junmedicinemedicine.disease_causeTranscription factorCell biology
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