6533b862fe1ef96bd12c6edf

RESEARCH PRODUCT

Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

Zsolt RadakZsolt RadakGianluca ScuderiMelinda CservenákKatsuhiro SuzukiÁRpád DobolyiDora AbrahamJános FehérMitsuru HiguchiSándor PongorJose ViñaBalázs LigetiBalázs LigetiDóra SzabóIstvan BoldoghMa Carmen Gómez-cabreraJános Juhász

subject

Male0301 basic medicineGenetically modified mouseAgingalzheimer; exercise; microbiome; probioticsalzheimermicrobiomeMice TransgenicPlaque AmyloidDiseaseHippocampusBiochemistrylaw.inventionAmyloid beta-Protein PrecursorMice03 medical and health sciencesProbiotic0302 clinical medicineEndocrinologyAlzheimer DiseaselawPhysical Conditioning Animalmental disordersPresenilin-1GeneticsAnimalsHippocampus (mythology)MedicineMicrobiomeMolecular BiologyAmyloid beta-Peptidesexercisebusiness.industryMicrobiotaCell BiologyDisease Models Animal030104 developmental biologyprobioticsImmunologybusiness030217 neurology & neurosurgery

description

Abstract It has been suggested that exercise training and probiotic supplementation could decelerate the progress of functional and biochemical deterioration in APP/PS1 transgenic mice (APP/PS1TG). APP/PS1TG mice were subjected to exercise training and probiotic treatments and functional, biochemical and microbiome markers were analyzed. Under these conditions the mice significantly outperformed controls on The Morris Maze Test, and the number of beta-amyloid plaques decreased in the hippocampus. B. thetaiotaomicron levels correlated highly with the results of the Morris Maze Test (p

yearjournalcountryeditionlanguage
2018-10-08Experimental Gerontology
https://doi.org/10.1016/j.exger.2018.12.005