0000000001180805
AUTHOR
C. Demougeot
FRI0044 Non-steroidal anti-inflammatory drugs are more beneficial than anti-tnfα drugs on the radiographic damage in arthritis: a study in adjuvant induced arthritis
Background The management of the chronic inflammatory rheumatisms has dramatically evolved in the last decade with a concept of “treat to target”. The theory of a window of opportunity with more beneficial effects of an early intensive treatment is supported by several evidences. The positive impact of an early treatment with a TNFα blocker is expected but the place and the interest of non-steroidal anti-inflammatory treatments (NSAIDs) and glucocorticoids is not clear. Objectives The aim of this study was to evaluate the radiological outcomes after an early treatment during 21 days by Etanercept, or Naproxene, or Celecoxib, or Prednisone, or Diclofenac or Methotrexate in adjuvant induced a…
Vasorelaxing effect of a TrkB receptor agonist on mesenteric arteries
International audience; Introduction: Brain-derived neurotrophic factor (BDNF) is a neurotrophin unanimously recognized for its promoting effect on neuroplasticity and cognition, through activation of tropomyosin receptor kinase B (TrkB). In opposition with the traditional thinking that neurons are the main source of BDNF, endothelial cells were found to express large amounts of BDNF. Exogenous BDNF was reported to exert vasodilating properties on isolated pulmonary artery and aorta. However, whether peripheral vascular resistances are controlled by endothelial BDNF is not known. To address this question, we investigated the vasorelaxant properties and the underlying signaling pathways of a…
Risque cardiovasculaire dans le rhumatisme psoriasique : revue narrative
Resume Introduction Le rhumatisme psoriasique (PsA) est un rhumatisme inflammatoire chronique caracterise de longue date par un risque cardiovasculaire important. Au cours des dernieres annees, les donnees epidemiologiques ont quelque peu change depuis l’utilisation croissante de biomedicaments efficaces pour reduire cette inflammation. L’objectif de cette revue est d’evaluer les donnees actuelles sur la morbidite et la mortalite cardiovasculaires dans le PsA et d’evaluer le risque cardiovasculaire en cas de PsA. Methode Nous avons effectue une revue de la litterature sur les bases de donnees Pubmed et Medline en utilisant les mots cles suivants : « Psoriatic Arthritis » et « Cardiovascular…
Human-based evidence for the therapeutic potential of arginase inhibitors in cardiovascular diseases
Arginase is a ubiquitous enzyme that regulates polyamine- and nitric-oxide-requiring vascular functions. It is well-established that, in mammals, arginase overactivation contributes to endothelial dysfunction, a hallmark of cardiovascular diseases. The pharmacological potential of arginase inhibition for improving vascular function is largely supported by a wide range of data from animal studies. However, caution is required before extrapolating animal data to humans because interspecies differences in arginase expression and localization have been observed. For this reason, this review presents the existing arguments from human data in favor of a role of arginase in cardiovascular diseases…
Effet de la cryothérapie locale sur l’inflammation vasculaire, la dysfonction endothéliale et l’activation endothéliale en cas d’arthrite
Introduction La polyarthrite rhumatoide (PR) est caracterisee par une surmortalite d’origine cardiovasculaire, qui est la consequence d’une dysfonction et d’une activation endotheliales (infiltration vasculaire par les cellules de l’immunite), et d’une inflammation vasculaire. Ces dernieres annees, un regain d’interet pour la cryotherapie locale ou corps entier en tant que therapie d’appoint a emerge. Alors que des donnees existent en faveur d’un effet positif de la cryotherapie locale sur la douleur et l’activite de la maladie, l’effet de ce type de strategie sur le risque cardiovasculaire est pour l’instant inconnu. L’objectif de notre etude a ete d’evaluer l’effet d’un traitement par cry…
AB0266 METHOTREXATE AND CARDIOVASCULAR RISK IN RHEUMATIC DISEASES:A COMPREHENSIVE REVIEW
Background:The management of inflammatory rheumatic disease has evolved in the last decade with the importance of the management of comorbidities. Methotrexate is the cornerstone of inflammatory rheumatic disease management, but its cardiovascular effects are still poorly understoodObjectives:To assess the cardiovascular impact of methotrexate in inflammatory rheumatic disease.Methods:A systematic review of the literature, following the prisma recommandations, was performed on the PubMed and Embase databases with the following keywords: (“Methotrexate”) AND (“cardiovascular”). We included papers written in English and including patients older than 18 years.Results:570 references were identi…
The Janus face of chlorogenic acid on vascular reactivity: A study on rat isolated vessels
Abstract Background Chlorogenic acid (CGA), the main polyphenol contained in coffee, is a major contributor to dietary polyphenol intake. Few studies reported its anti-hypertensive properties but the mechanisms are still indefinite. Purpose The present study assessed the direct effect of CGA in endothelium denuded or intact aortic rings from male Wistar rats and the mechanisms involved. Methods/Results CGA induced a direct endothelium-dependent relaxation that was significantly reduced by L-NAME (10 −4 M), indomethacin (10 −5 M) and combination of apamin (10 −7 M) and charybdotoxin (10 −7 M). Incubation of rings with CGA induced a dual effect on agonist-induced vasorelaxation. At 10 −6 …
''Expression of endothelial brain-derived neurotrophic factor is dependent on endothelial function''
Quirie, A. | Prigent-Tessier, A. | Mossiat, C. | Nappey, M. | Marie, C. | Demougeot, C.; International audience
Cardiovascular risk in psoriatic arthritis, a narrative review
Abstract Introduction Psoriatic arthritis (PsA) is a chronic inflammatory rheumatism characterized for a long time by a high degree of cardiovascular risk. Chronic inflammation is one of the mechanisms that explain this cardiovascular excess of risk through direct and indirect pathways. In recent years, epidemiological data have changed somewhat since the increasing use of bio-drugs that are effective in reducing this inflammation. The purpose of this review is to assess the current state of cardiovascular morbidity and mortality in PsA and thus to assess the cardiovascular risk in case of PsA. Method We conducted a literature review using Pubmed and Medline databases with the following key…
Association between endothelial dysfunction and brain BDNF levels in a rat model of arthritis
International audience
Impact of glucocorticoids on systemic sirtuin 1 expression and activity in rats with adjuvant-induced arthritis
The class III histone deacetylase sirtuin 1 (SIRT1) plays a pivotal role in numerous biological and physiological functions, including inflammation. An association between SIRT1 and proinflammatory cytokines might exist. In addition to their important role in inflammation associated with rheumatoid arthritis (RA), proinflammatory cytokines mediate the development of systemic effects. Here, we evaluated systemic SIRT1 expression and enzymatic activity, in peripheral blood mononuclear cells (PBMCs) and in liver isolated from rats with adjuvant-induced arthritis (AIA), treated or not with low or high doses of glucocorticoids (GCs). We also measured the production of tumour necrosis factor alph…
MYOCARDIAL POTENCY OF AQUEOUS EXTRACT OF HARUNGANA MADAGASCARIENSIS STEM BARK AGAINST ISOPROTERENOL-INDUCED MYOCARDIAL DAMAGE IN RATS
Objectives: The present study was undertaken to evaluate the effects of Harungana madagascariensis on electrocardiographical, biochemical and histopathological changes in isoproterenol (ISO)-induced myocardial infarction in rats. Methods: Male Wistar albino rats were randomly divided and treated with the aqueous extract of Harungana madagascariensis stem bark (AEHM, 200 and 400 mg/kg per os), or normal saline or vitamin E for 7 days with concomitant administration of ISO (85 mg/kg, subcutaneously) on 8th and 9th days, at 24 h interval. Results: The ISO injections to the rats caused cardiac dysfunction evidenced by a marked (P<0.01) elevation in ST-segment, a reduction in R wave amplitude (P…