0000000001192353
AUTHOR
Virginia Spano'
A Convenient Synthesis of Pyrano[2,3-e]isoindol-2-one : a new heteroanalogue of angelicin
4,5,6,9-TETRAHYDROPYRROLO[2',3'-3,4]CYCLOEPTA[1,2-d]ISOSSAZOLE, PROCESS FOR THEIR PRODUCTION AND THEIR USES AS ANTITUMOR AGENTS
The present invention concerns the synthesis of compounds bearing the PYRROLO[2',3'-3,4]CYCLOEPTA[1,2-d]ISOSSAZOLE structure, and their use for the treatment of pathologies having hyperproliferative features included those having neoplastic nature.
Pyrazolo[3,4-h]quinolin-2-ones with photobiological properties
Pyrazolo[3,4-h]quinolines as potent photosensitizer agents
[1,2]oxazole[5,4-e]isoindoles as promising drugs for anticancer chemotherapy
Quality characteristic and in vitro digestibility study of barley flour enriched ditalini pasta
In vitro digestion of beta glucan enriched pasta: polysaccharide molecular characterization and antioxidant activity of bioaccessible fraction.
Novel 1H‑Pyrrolo[2,3‑b]pyridine Derivative Nortopsentin Analogues: Synthesis and Antitumor Activity in Peritoneal Mesothelioma Experimental Models
In this study, we describe the synthesis of new nortopsentin analogues, 1H-pyrrolo[2,3-b]pyridine derivatives and their biological effects in experimental models of diffuse malignant peritoneal mesothelioma (DMPM), a rare and rapidly fatal disease, poorly responsive to conventional therapies. The three most active compounds, 1f (3-[2-(5-fluoro-1-methyl-1H-indol-3- yl)-1,3-thiazol-4-yl]-1H-pyrrolo[2,3-b]pyridine), 3f (3-[2-(1H-indol-3-yl)-1,3- thiazol-4-yl]-1-methyl-1H-pyrrolo[2,3-b]pyridine), and 1l (3-[2-(5-fluoro-1- methyl-1H-indol-3-yl)-1,3-thiazol-4-yl]-1-methyl-1H-pyrrolo[2,3-b] pyridine), which were shown to act as cyclin-dependent kinase 1 inhibitors, consistently reduced DMPM cell p…
Synthesis and antitumor activity of new 7-azaindole derivative nortopsentin analogues
Isoxazolo[5,4-e]isoindole a new ring system with potent antitumor activity
Biological evaluation of Pyrrolo[3,4-h]quinazolines
Pirazolo[3,4-h]chinoline come nuova classe di agenti fotosensibilizzanti
Composti a struttura ossazolica, procedimenti per la loro produzione e loro impiego per la cura di patologie a carattere iperproliferativo
La presente invenzione riguarda composti che presentano nella loro struttura il sistema eterociclico [1,2]Ossazolo[5,4-e]isoindolo, un procedimento per la oro produzione e il loro impiego per la cura di patologie a carattere iperproliferativo comprese quelle di natura neoplastica. I nuovi derivati saggiati al National Cancer Institute di Bethesda su un 60 linee cellulari umane divise in 9 sottopannelli (mammella, ovaie, polmone, colon, SNC, melanoma, leucemia, rene, prostata), hanno mostrato attività antiproliferativa da micro a nanomolare, rivelando alcuni derivati particolarmente promettenti.
2-substituted-[1,3]thiazolo[4,5-e]isoindoles as kinases inhibiting compounds
SYNTHESIS AND PHOTOBIOLOGICAL ACTIVITY OF PYRROLO-FUSED HETEROCYCLES
4,5,6,9-tetraidropirrolo[2',3':3,4] cicloepta[1,2-d] isossazoli, procedimento per la loro produzione e loro uso come antitumorali
La presente invenzione riguarda derivati a struttura 4,5,6,9- tetraidropirrolo[2',3':3,4]cicloepta[1,2-d]isossazolica, procedimenti per la loro produzione e il loro uso per la cura di patologie a carattere iperproliferativo comprese quelle di natura neoplastica. I nuovi derivati saggiati al National Cancer Institute di Bethesda su un pannello di circa 60 linee cellulari umane divise in 9 sottopannelli (mammella, ovaie, polmone, colon, SNC, melanoma, leucemia, rene, prostata), hanno mostrato attività antiproliferativa da micro a nanomolare, rivelando alcuni derivati particolarmente promettenti
Editorial: Emerging heterocycles as bioactive compounds
Heterocycles represent a privileged scaffold due to their ability to interact with biological systems via heteroatoms. It is no coincidence that every year the Food and Drug Administration approves numerous new drugs that contain at least one heterocyclic system as active pharmacophoric part in their structure. Many heterocyclic compounds with therapeutic properties, including anticancer, antimicrobial, anti-inflammatory and so on, come from natural sources such as plants and animals, and medicinal chemists very often use them to study their chemical space and improve their biological activity. In fact, several efficient approaches for the formation of aromatic heterocyclic compounds and th…
PYRANO[2,3-E]ISOINDOL-2-ONE: A NEW RING SYSTEM WITH POTENTIAL PHOTOBIOLOGICAL PROPERTIES
PYRROLO[3,4-H]QUINAZOLINES WITH ANTITUMOR ACTIVITY
SINTESI DI NUOVI DERIVATI[2,3-E]ISOINDOL-2-ONI A POTENZIALE ATTIVITA' FOTOCHEMIOTERAPICA
Pyrrolo-fused heterocycles as photochemotherapeutic agents
New topoisomerase I inhibitors with condensed-azaindole structure
In vitro digestion of beta glucan enriched pasta and antioxidant potential of digesta
NUOVI COMPOSTI PIRAZOLO[3,4-H]CHINOLINICI, LORO PREPARAZIONE ED USO MEDICO
La presente invenzione si riferisce al campo dei composti pirazolo[3,4-h]chinolinici, loro preparazione ed uso medico, in particolare per la cura di patologie a carattere iperproliferativo comprese quelle di natura neoplastica.