0000000001216892

AUTHOR

L. Fratiglioni

showing 3 related works from this author

Il ruolo dei fattori di rischio vascolare nei sottotipi di Mild Cognitive Impairment: risultati del progetto ReGAl

2007

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Association of Antidementia Drugs and Mortality in Community-Dwelling Frail Older Patients With Dementia: The Role of Mortality Risk Assessment

2018

Objective: To evaluate whether treatment with antidementia drugs is associated with reduced mortality in older patients with different mortality risk at baseline. Design: Retrospective. Setting: Community-dwelling. Participants: A total of 6818 older people who underwent a Standardized Multidimensional Assessment Schedule for Adults and Aged Persons (SVaMA) evaluation to determine accessibility to homecare services or nursing home admission from 2005 to 2013 in the Padova Health District, Italy were included. Measurements: Mortality risk at baseline was calculated by the Multidimensional Prognostic Index (MPI), based on information collected with the SVaMA. Participants were categorized to …

MaleGerontologymedicine.medical_specialtyFrail ElderlyMultidimensional assessmentantidementia drugLower riskComprehensive geriatric assessmentRisk AssessmentArticle03 medical and health sciences0302 clinical medicineOlder patientsSDG 3 - Good Health and Well-beingRisk Factorsantidementia drugs; comprehensive geriatric assessment; Dementia; frailty; mortality; multidimensional prognostic index (MPI); Nursing (all)2901 Nursing (miscellaneous); Health Policy; Geriatrics and GerontologyInternal medicinemedicineHumansDementia030212 general & internal medicineMultidimensional prognostic index (MPI)MortalityGeriatric AssessmentNursing (all)2901 Nursing (miscellaneous)General NursingAgedRetrospective StudiesAged 80 and overFrailtybusiness.industryHealth PolicyHazard ratioGeneral Medicinemedicine.diseaseSurvival AnalysisConfidence intervalAntidementia drugs; Comprehensive geriatric assessment; Dementia; Frailty; Mortality; Multidimensional prognostic index (MPI); Nursing (all)2901 Nursing (miscellaneous); Health PolicyAntidementia drugsFemaleDementiaIndependent LivingGeriatrics and GerontologyNursing homesbusinessRisk assessment030217 neurology & neurosurgery
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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

2013

Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer's disease cases and 37,154 controls. In stage 2, 11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer's disease cases and 11,312 controls. In addition to the APOE locu…

MaleApolipoprotein Eepidemiology [Alzheimer Disease]SORL1Medizingenetics [Alzheimer Disease]Genome-wide association studySingle-nucleotide polymorphismBiologyPolymorphism Single NucleotideArticlePICALMCohort StudiesAlzheimer Diseaseddc:570PSEN2GeneticsmedicineHumansGenetic Predisposition to DiseaseAge of OnsetBiologyAgedGenetic associationAged 80 and overGeneticsMiddle Agedmedicine.diseaseGenetic LociCase-Control StudiesFemaleHuman medicineAlzheimer's diseasestatistics & numerical data [Genome-Wide Association Study]Genome-Wide Association StudyNature Genetics
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