0000000001230839
AUTHOR
V. Marco
HepatomiRNoma: The proposal of a new network of targets for diagnosis, prognosis and therapy in hepatocellular carcinoma
Abstract: The diagnosis and treatment of hepatocellular carcinoma (HCC) underwent a huge advancement in the last years. Recently, microRNAs (miRNAs) have been also studied to provide a new tool for early diagnosis of high risk patients, for prognostic classification to identify those patients who benefit cancer treatment and for predictive definition to select the right targeted drug. In this review we revised all the available data obtained to explore the role of miRNAs in HCC. This analysis led to identification of miRNAs which could gain a diagnostic, prognostic or predictive role. The results of studies on miRNAs involved in HCC are initial and far from providing scientific evidences to…
Influence of endothelial nitric oxide on neurogenic contraction of human pulmonary arteries.
The present study was designed to investigate the contribution of the endothelium and that of the L-arginine pathway on the contractile responses of isolated human pulmonary arteries to electrical field stimulation (EFS) and noradrenaline. Isometric tension was measured in artery rings obtained from portions of human lung after thoracic surgery for removal of lung carcinoma (18 patients). Electrical field stimulation (EFS) induced frequency-dependent contractions of isolated human pulmonary arteries which were abolished by tetrodotoxin, guanethidine and prazosin (all at 10(-6) M). The increases in tension were of greater magnitude in arteries denuded of endothelium. NG-nitro-L-arginine meth…
Tratamiento quirúrgico de las roturas del tendón de Aquiles
El objetivo del trabajo fue valorar los resultados y complicaciones obtenidos tras tratamiento quirúrgico de las rupturas subcutáneas del tendón de Aquiles. Se revisaron 26 pacientes, con un seguimiento mínimo de 1 año. Detallamos nuestra metodología en cuanto a técnica quirúrgica y manejo postoperatorio. Se valoró el resultado clínico según los siguientes parámetros: movilidad de tobillo, potencia muscular tríceps, engrosamiento tendinoso, claudicación a la marcha, atrofia gemelar, incorporación a actividades deportivas y alteraciones residuales. Los resultados fueron muy buenos en 21 casos (80,7%); buenos en 5 (19,3%), y ningún caso con resultado regular o malo. Destacamos 5 complicacione…