HepatomiRNoma: The proposal of a new network of targets for diagnosis, prognosis and therapy in hepatocellular carcinoma

6533b7d5fe1ef96bd126525a

RESEARCH PRODUCT

HepatomiRNoma: The proposal of a new network of targets for diagnosis, prognosis and therapy in hepatocellular carcinoma

Fabrizio Bronte Giuseppe Bronte Daniele Fanale Stefano Caruso Enrico Bronte Maria Grazia Bavetta Eugenio Fiorentino Christian Diego Rolfo Viviana Bazan V. Marco Antonio Russo Vincenza Calvaruso

subject

Serum 0301 basic medicine Carcinoma Hepatocellular Hepatocellular carcinoma Prognosi medicine.medical_treatment Bioinformatics Targeted therapy Targeted therapy 03 medical and health sciences 0302 clinical medicine Prognostic classification Biomarkers Tumor medicine Humans Prospective cohort study High risk patients business.industry Liver Neoplasms MicroRNA Hematology Prognosis medicine.disease Cancer treatment Clinical Practice MicroRNAs 030104 developmental biology Oncology 030220 oncology & carcinogenesis Hepatocellular carcinoma Human medicine Diagnosis; Hepatocellular carcinoma; MicroRNA; Prognosis; Serum; Targeted therapy; Hematology; Oncology; Geriatrics and Gerontology Geriatrics and Gerontology business Diagnosi

description

Abstract: The diagnosis and treatment of hepatocellular carcinoma (HCC) underwent a huge advancement in the last years. Recently, microRNAs (miRNAs) have been also studied to provide a new tool for early diagnosis of high risk patients, for prognostic classification to identify those patients who benefit cancer treatment and for predictive definition to select the right targeted drug. In this review we revised all the available data obtained to explore the role of miRNAs in HCC. This analysis led to identification of miRNAs which could gain a diagnostic, prognostic or predictive role. The results of studies on miRNAs involved in HCC are initial and far from providing scientific evidences to translate into clinical practice. We propose a classification of these miRNAs, that we could name HepatomiRNoma as a whole. Anyway prospective studies have to be designed to clarify the real clinical impact of this new tool. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

year	journal	country	edition	language
2015-05-14	Critical Reviews in Oncology/Hematology

https://doi.org/10.1016/j.critrevonc.2015.09.007

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