0000000001263538
AUTHOR
S. Spina
Analisi dendrocronologiche nel sito Natura 2000 “Pineta di Linguaglossa”
Dendrochronology is based on the tree’s characteristic to register in their xylem, the environmental conditions in which they live. The influence of climate, soil movements and modifications, volcanic eruptions, insect attacks etc, determine ring width and further xylem morphological elements (cell lumen, density, latewood and earlywood width etc.). Tree rings may be used as proxy records. According to this assumption, the correlation between tree rings and environmental factors may be transposed back in time using long chronologies, in order to reconstruct specific environmental conditions such as climate, hydrological fluctuations, ice movements etc. The aim of the project Managmned is to…
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer's disease cases and 37,154 controls. In stage 2, 11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer's disease cases and 11,312 controls. In addition to the APOE locu…