0000000001293141

AUTHOR

L. Mearini

showing 2 related works from this author

How radical prostatectomy procedures have changed over the last 10 years in Italy: a comparative analysis based on more than 1500 patients participat…

2020

Purpose Therapeutic strategies for prostate cancer (PCa) have been evolving dramatically worldwide. The current article reports on the evolution of surgical management strategies for PCa in Italy. Methods The data from two independent Italian multicenter projects, the MIRROR-SIU/LUNA (started in 2007, holding data of 890 patients) and the Pros-IT-CNR project (started in 2014, with data of 692 patients), were compared. Differences in patients' characteristics were evaluated. Multivariable logistic regression models were used to identify characteristics associated with robot-assisted (RA) procedure, nerve sparing (NS) approach, and lymph node dissection (LND). Results The two cohorts did not …

MaleNephrologymedicine.medical_specialtyTime FactorsUrologymedicine.medical_treatment030232 urology & nephrologyLymph node dissectionLogistic regression03 medical and health sciencesProstate cancer0302 clinical medicineInternal medicineLUNA studyBiopsyHumansMedicineProspective StudiesNerve sparingLymph nodeAgedProstatectomyProstate cancermedicine.diagnostic_testbusiness.industryProstatectomyMIRROR SIU/LUNA studyLymph node dissection MIRROR SIU/LUNA study Nerve sparing Pros-IT CNR study Prostate cancer Robotic proceduresProstatic NeoplasmsCancerPros-IT CNR studyMiddle Agedmedicine.diseaseMIRROR SIUDissectionRobotic proceduresLogistic Modelsmedicine.anatomical_structureItaly030220 oncology & carcinogenesisLymph node dissection; MIRROR SIU/LUNA study; Nerve sparing; Pros-IT CNR study; Prostate cancer; Robotic procedures; Aged; Humans; Italy; Logistic Models; Male; Middle Aged; Prospective Studies; Prostatectomy; Prostatic Neoplasms; Time FactorsLymph node dissection; MIRROR SIU/LUNA study; Nerve sparing; Pros-IT CNR study; Prostate cancer; Robotic proceduresbusiness
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External Validation of Nomogram Predicting the Probability of Specimen-Confined Disease (pT2-3a, R0N0) in Patients Undergoing Radical Prostatectomy a…

2014

Introduction: Before radical prostatectomy (RP), a nomogram [Briganti et al., Eur Urol 2012;61:584-592] permits to measure the probability of specimen-confined (SC) disease (pT2-pT3a, node negative with negative margins) in high-risk prostate cancer (PCa). The aim of our study was to perform an external validation of this nomogram. Materials and Methods: Between 2007 and 2011, 623 patients with high-risk PCa (prostate-specific antigen (PSA) >20 ng/ml and/or biopsy Gleason score ≥8 and/or clinical stage T3) underwent RP and pelvic lymph node dissection at tertiary referral centers. Multivariable logistic regression models predicting the presence of SC disease were built in; we then used the …

AdultMaleHigh-risk prostate cancermedicine.medical_specialtyUrologymedicine.medical_treatmentHigh-risk prostate cancer; Nomogram; Radical prostatectomyUrologyReproducibility of ResultRadical prostatectomy; High-risk prostate cancer; Nomogramurologic and male genital diseasesSensitivity and SpecificityRegression AnalysiNomogramCohort StudiesRisk FactorsmedicineHumansIn patientMultivariate AnalysiLymph nodeAgedProbabilityAged 80 and overProstatectomyProstatectomybusiness.industryRisk FactorExternal validationProstatic NeoplasmsReproducibility of ResultsMiddle AgedProstate-Specific AntigenNomogramRadical prostatectomyNomogramsProstate-specific antigenDissectionmedicine.anatomical_structureROC CurveProstatic NeoplasmCalibrationMultivariate AnalysisLymph Node ExcisionRegression AnalysisCohort StudiebusinessHuman
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