How radical prostatectomy procedures have changed over the last 10 years in Italy: a comparative analysis based on more than 1500 patients participating in the MIRROR-SIU/LUNA and the Pros-IT CNR study

6533b82bfe1ef96bd128cde2

RESEARCH PRODUCT

How radical prostatectomy procedures have changed over the last 10 years in Italy: a comparative analysis based on more than 1500 patients participating in the MIRROR-SIU/LUNA and the Pros-IT CNR study

M. Gacci W. Artibani P. Bassi F. Bertoni S. Bracarda A. Briganti G. Carmignani L. Carmignani G. Conti R. Corvo C. De Nunzio F. Fusco P. Graziotti I. Greco S. Maggi S. M. Magrini V. Mirone R. Montironi G. Morgia G. Muto M. Noale S. Pecoraro A. Porreca U. Ricardi E. Russi G. Russo A. Salonia A. Simonato S. Serni D. Tomasini A. Tubaro V. Zagonel G. Crepaldi G. N. Conti M. Gacci A. R. Alitto E. Ambrosi A. Antonelli C. Aristei F. Bardari L. Bardoscia S. Barra S. Bartoncini U. Basso C. Becherini R. Bellavita F. Bergamaschi S. Berlingheri A. Berruti M. Borghesi R. Bortolus V. Borzillo D. Bosetti G. Bove P. Bove M. Brausi A. Bruni G. Bruno E. Brunocilla A. Buffoli M. Buglione C. Buttigliero G. Cacciamani M. Caldiroli G. Cardo G. Carrieri E. Castelli E. Castrezzati G. Catalano S. Cattarino F. Catucci D. Cavallini Francolini O. Ceccarini A. Celia F. Chiancone T. Chini C. Cianci A. Cisternino D. Collura F. Corbella M. Corinti P. Corsi F. Cortese L. Corti N. Decosimo O. Cristiano D. A. Rolando L. Da Pozzo D. D'agostino C. D'elia M. Dandrea M. De Angelis P. De Angelis O. De Cobelli B. De Concilio A. De Lisa S. De Luca A. De Stefani C. L. Deantoni C. Degli Esposti A. Destito B. Detti N. Di Muzio A. Di Stasio C. Di Stefano D. Di Trapani G. Difino S. Falivene G. Farullo P. Fedelini I. Ferrari F. Ferrau M. Ferro A. Fodor F. Fontana F. Francesca G. Francolini P. Frata G. Frezza P. Gabriele M. Galeandro E. Garibaldi P. G. Gennari A. Gentilucci A. Giacobbe L. Giussani G. Giusti P. Gontero A. Guarneri C. Guida A. Gurioli D. Huqi C. Imbimbo G. Ingrosso C. Iotti C. Italia P. La Mattina R. La Rocca E. Lamanna L. Lastrucci G. Lazzari F. Liberale G. Liguori R. Lisi F. Lohr R. Lombardo J. A. Lovisolo G. M. Ludovico N. Macchione F. Maggio M. Malizia G. Manasse G. Mandoliti G. Mantini L. Marafioti L. Marciello A. M. Marconi A. Martilotta S. Marzano S. Masciullo G. Maso A. Massenzo E. Mazzeo L. Mearini S. Medoro R. Mole G. Monesi E. Montanari F. Montefiore G. Montesi G. Moro G. Muscas D. Musio P. Muto G. Muzzonigro G. Napodano C. L. A. Negro M. Nidini M. Ntreta M. Orsatti C. Palazzolo I. Palumbo A. Parisi P. Parma N. Pavan M. Pericolini F. Pinto A. Pistone V. Pizzuti A. Platania C. Polli G. Pomara E. Ponti A. B. Porcaro F. Porpiglia D. Pugliese A. Pycha G. Raguso A. Rampini D. F. Randone V. Roboldi M. Roscigno M. P. Ruggieri G. Ruoppo R. Sanseverino A. Santacaterina M. Santarsieri R. Santoni S. Scagliarini G. V. Scagliotti M. Scanzi M. Scarcia R. Schiavina A. Sciarra C. Sciorio T. Scolaro S. Scuzzarella O. Selvaggio A. Serao M. A. Signor M. Silvani G. Silvano F. Silvestris C. Simeone V. Simone G. Spagnoletti M. G. Spinelli L. Squillace V. Tombolini M. Toninelli L. Triggiani A. Trinchieri L. Trodella E. Luca L. Trodella C. Trombetta L. Tronnolone M. Tucci D. Urzi R. Valdagni M. Valeriani M. Vanoli E. Vitali A. Volpe S. Zaramella G. Zeccolini G. Zini F. Acanfora E. Aiello S. Alchiede V. Altieri C. Anceschi F. Aragona F. Balloni E. Barasolo G. Barba R. Bartoletti B. Bigazzi E. Belgrano S. Salvatore M. Battaglia L. Bellei A. Bettin G. Bianchi L. Bombieri T. Brancato G. Breda S. Caggiano A. Calabro M. Caldironi B. Campo S. Capobianco F. Capparelli A. Carbone D. Carlo G. Catalano F. Catanzaro F. Ciaraldi V. Cicalese A. Cisternino C. Corbu S. Cosciani Cunico V. Cosentino A. Crimi G. Cucchiarale D. Cuscuna R. Damiano M. D'armiento O. De Cobelli C. De Dominicis G. De Grande C. Del Boca A. D'elia A. De Lisa S. De Luca E. De Mayo M. De Martin L. Di Clemente S. Di Meo G. Di Monaco G. Di Nicola A. Di Silverio F. Di Silverio F. Fabri M. Falsaperla F. Fanciullacci G. Ferrari G. Fiaccavento A. Filoni D. Fontana G. Fontana H. Ghabin B. Frea F. Gaboardi M. Gacci V. Gentile M. Giandotti P. Gontero M. Grasso G. Grosso S. Guazzieri A. Isaia G. Landi R. Landolfi P. Larcher C. Laurenti D. Lavelli G. L. Leidi A. Lembo S. Leoni G. M. Ludovico N. Maffei M. Maffezzini C. Martinengo C. Manieri A. M. Marconi G. Martorana R. Mazza M. Medica D. Melloni L. Miano E. Micheli R. Milesi M. S. Minervini D. Minocci A. Molon E. Montanari P. Morello M. Motta G. Muzzonigro F. Narcisi G. Nicita S. Palermo M. Paoluzzi P. Parma P. Pompa M. Porena G. Raciti D. F. Randone A. Rizzotto F. Rocco M. Romano L. Rossini G. R. Russo R. Salvioni S. Sandri G. Savoca C. Selli F. P. Selvaggi F. Sercia C. Tallarigo M. Tanello A. Tasca R. Tenaglia M. Tensi C. Terrone L. Tralce A. Trinchieri A. Vagge P. Valenti M. Varaldo G. Vespasiani C. Vicentini F. Vicirca P. Vigano V. Zaccone C. Zartar

subject

Male Nephrology medicine.medical_specialty Time Factors Urology medicine.medical_treatment 030232 urology & nephrology Lymph node dissection Logistic regression 03 medical and health sciences Prostate cancer 0302 clinical medicine Internal medicine LUNA study Biopsy Humans Medicine Prospective Studies Nerve sparing Lymph node Aged Prostatectomy Prostate cancer medicine.diagnostic_test business.industry Prostatectomy MIRROR SIU/LUNA study Lymph node dissection MIRROR SIU/LUNA study Nerve sparing Pros-IT CNR study Prostate cancer Robotic procedures Prostatic Neoplasms Cancer Pros-IT CNR study Middle Aged medicine.disease MIRROR SIU Dissection Robotic procedures Logistic Models medicine.anatomical_structure Italy 030220 oncology & carcinogenesis Lymph node dissection; MIRROR SIU/LUNA study; Nerve sparing; Pros-IT CNR study; Prostate cancer; Robotic procedures; Aged; Humans; Italy; Logistic Models; Male; Middle Aged; Prospective Studies; Prostatectomy; Prostatic Neoplasms; Time Factors Lymph node dissection; MIRROR SIU/LUNA study; Nerve sparing; Pros-IT CNR study; Prostate cancer; Robotic procedures business

description

Purpose Therapeutic strategies for prostate cancer (PCa) have been evolving dramatically worldwide. The current article reports on the evolution of surgical management strategies for PCa in Italy. Methods The data from two independent Italian multicenter projects, the MIRROR-SIU/LUNA (started in 2007, holding data of 890 patients) and the Pros-IT-CNR project (started in 2014, with data of 692 patients), were compared. Differences in patients' characteristics were evaluated. Multivariable logistic regression models were used to identify characteristics associated with robot-assisted (RA) procedure, nerve sparing (NS) approach, and lymph node dissection (LND). Results The two cohorts did not differ in terms of age and prostate-specific antigen (PSA) levels at biopsy. Patients enrolled in the Pros-IT-CNR project more frequently were submitted to RA (58.8% vs 27.6%,p < 0.001) and NS prostatectomy (58.4% vs. 52.9%,p = 0.04), but received LND less frequently (47.7% vs. 76.7%,p < 0.001), as compared to the MIRROR-SIU/LUNA patients. At multivariate logistic models, Lower Gleason Scores (GS) and PSA levels were significantly associated with RA prostatectomy in both cohorts. As for the MIRROR-SIU/LUNA data, clinical T-stage was a predictor for NS (OR = 0.07 for T3, T4) and LND (OR = 2.41 for T2) procedures. As for Pros-IT CNR data, GS >= (4 + 3) and positive cancer cores >= 50% were decisive factors both for NS (OR 0.29 and 0.30) and LND (OR 7.53 and 2.31) strategies. Conclusions PCa management has changed over the last decade in Italian centers: RA and NS procedures without LND have become the methods of choice to treat newly medium-high risk diagnosed PCa.

year	journal	country	edition	language
2020-04-22

10.1007/s00345-020-03350-5 https://hdl.handle.net/2318/1845715